A1. OBJECTIVE The overall objective of the Administrative Core is to facilitate the mission of this IDDRC. Thus, the goals of the Administrative Core are to ensure that 1) research in this Center is focused on problems of relevance and importance to intellectual and developmental disabilities, 2) the research is organized around clearly-defined themes, 3) the research is of the highest scientific quality, 4) there is facilitation of multidisciplinary research and research training, 5) translation of basic research findings to clinical application has high priority, and 6) there is fostering of """"""""centerness"""""""", that leads to synergistic, collaborative interactions between IDDRC investigators. We believe that the activities outlined throughout this grant (see Progress Report, Core Descriptions, and Research Projects Proposed for Core Usage) demonstrate that we are achieving these goals, and it is our intention to build upon our previous successes during the next funding period.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-32
Application #
8509725
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
32
Fiscal Year
2013
Total Cost
$454,725
Indirect Cost
$193,389
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Boulay, Gaylor; Awad, Mary E; Riggi, Nicolo et al. (2017) OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma. Cancer Discov 7:288-301
Su, Cathy; Schwarz, Thomas L (2017) O-GlcNAc Transferase Is Essential for Sensory Neuron Survival and Maintenance. J Neurosci 37:2125-2136
Kuban, Karl C K; Joseph, Robert M; O'Shea, Thomas M et al. (2017) Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm. J Pediatr 180:116-123.e1
Cartoni, Romain; Pekkurnaz, Gulcin; Wang, Chen et al. (2017) A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. PLoS One 12:e0184672
Lisi, VĂ©ronique; Singh, Bhagat; Giroux, Michel et al. (2017) Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. Cell Rep 20:1136-1147
Joseph, Robert M; Korzeniewski, Steven J; Allred, Elizabeth N et al. (2017) Extremely low gestational age and very low birthweight for gestational age are risk factors for autism spectrum disorder in a large cohort study of 10-year-old children born at 23-27 weeks' gestation. Am J Obstet Gynecol 216:304.e1-304.e16
Jamuar, Saumya S; Schmitz-Abe, Klaus; D'Gama, Alissa M et al. (2017) Biallelic mutations in human DCC cause developmental split-brain syndrome. Nat Genet 49:606-612
Jensen, Elizabeth T; van der Burg, Jelske W; O'Shea, Thomas M et al. (2017) The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm. J Pediatr 187:50-57.e3
Tischfield, Max A; Robson, Caroline D; Gilette, Nicole M et al. (2017) Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura. Dev Cell 42:445-461.e5
Yanni, Diana; Korzeniewski, Steven J; Allred, Elizabeth N et al. (2017) Both antenatal and postnatal inflammation contribute information about the risk of brain damage in extremely preterm newborns. Pediatr Res 82:691-696

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