The Biostatistics and Bioinformatics Core, now in its 20th year of continuous funding, received an 'outstanding' rating in 2005. The existing Core supports IDDRC researchers in experimental design and biostatistical analysis of data from traditional sources, as well as studies that use genomic and functional genomic data. Support for bioinformatics is increasingly important for our users. The proposed Core retains our existing strengths in biostatistics and statistical genetics while strengthening support for bioinformatics. During the current funding cycle, Dr. Avital Cnaan, the Core Director, relocated to Children's National Medical Center while Dr. David Shera, a biostatistician, took a position with the pharmaceutical industry. Dr. Mary Putt became Director in 2006, continuing a productive history with the IDDRC that began as Associate Director in 1999. Dr. Marcella Devoto, a statistical geneticist, and Dr. Peter Yang, a biostatistician, were recruited to join the Core. The proposed renewal adds Dr. Peter White as co-director. Dr. White, who is nationally known for his work in genomics and bioinformatics, directs the Center for Biomedical Informatics (CBMi) at CHOP. With the tremendous growth of genomics in both basic science and clinical research at Children's Hospital of Philadelphia and the University of Pennsylvania, our new efforts for this renewal focus on strengthening support for genomic and functional genomics studies, particularly bioinformatics.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD026979-24
Application #
8523935
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
24
Fiscal Year
2013
Total Cost
$189,263
Indirect Cost
$42,178
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Carlson, G C; Lin, R E; Chen, Y et al. (2016) Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating. Neuroscience 322:408-15
Chen, Yong; Bang, Sookhee; McMullen, Mary F et al. (2016) Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia. Mol Neurobiol :
Ghosh, Mausam; Lane, Meredith; Krizman, Elizabeth et al. (2016) The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element. J Neurochem 136:262-75
Opladen, Thomas; Lindner, Martin; Das, Anibh M et al. (2016) In vivo monitoring of urea cycle activity with (13)C-acetate as a tracer of ureagenesis. Mol Genet Metab 117:19-26
Port, Russell G; Gaetz, William; Bloy, Luke et al. (2016) Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD. Autism Res :
White, Rachel S; Bhattacharya, Anup K; Chen, Yong et al. (2016) Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1. Mol Brain 9:38
Edgar, J Christopher; Fisk 4th, Charles L; Liu, Song et al. (2016) Translating Adult Electrophysiology Findings to Younger Patient Populations: Difficulty Measuring 40-Hz Auditory Steady-State Responses in Typically Developing Children and Children with Autism Spectrum Disorder. Dev Neurosci 38:1-14
Port, Russell G; Edgar, J Christopher; Ku, Matthew et al. (2016) Maturation of auditory neural processes in autism spectrum disorder - A longitudinal MEG study. Neuroimage Clin 11:566-77
Antezana, Ligia; Mosner, Maya G; Troiani, Vanessa et al. (2016) Social-Emotional Inhibition of Return in Children with Autism Spectrum Disorder Versus Typical Development. J Autism Dev Disord 46:1236-46
Mlynarski, Elisabeth E; Xie, Michael; Taylor, Deanne et al. (2016) Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome. Hum Genet 135:273-85

Showing the most recent 10 out of 303 publications