The Department of Pediatrics, Baylor College of Medicine (BCM), proposes- that a Child Health Research Center (CHRC) would formalize the tradition of the Department and the College of applying basic science technology to improve our understanding and management of clinical pediatric problems. To this and Baylor would develop the Molecular Medicine Approaches to Pediatrics (MMAP) Program, funded in part by the CHRC core grant, which would recruit and provide extended training to young investigators and bring the complementary experimental approaches and technologies of developmental biology, molecular genetics and cell biology to bear on clinically relevant problems in pediatrics. The objectives of the CHRC would be: (a) To increase the number and effectiveness of pediatric investigators engaged in molecular medicine research by attracting and mentoring young pediatrician-investigators, developing innovative and flexible programs to accommodate the individuals"""""""" needs, and encouraging students, residents and fellows to consider careers in """"""""locular medicine and pediatrics; (b)To facilitate the research of now and established investigators by providing a shared Core Laboratory; (c) To develop the mentoring skills of our younger established investigators including MMAP Program graduates; and (d) To provide increased opportunities for creative interdisciplinary. research by bringing together basic scientists and pediatric investigators. In order to accomplish these objectives, the proposed CHRC has recruited 32 established investigators funded by NIH who have active research interests in molecular medicine as it relates to pediatrics: 17 with primary appointments in Pediatrics and 15 with primary appointments in 6 basic science departments. Eleven pediatric subspecialties are represented among these investigators. These established investigators would serve as mentors for the New Project Development investigators. The Baylor CHRC would be a center of excellence for mo- lecular medicine research in pediatrics which would foster career development of new investigators, and facilitate the research activities of new and established investigators, in order to benefit the health of children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD027823-05
Application #
2200663
Study Section
Special Emphasis Panel (SRC (LJ))
Project Start
1990-09-30
Project End
1995-11-30
Budget Start
1994-09-01
Budget End
1995-11-30
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Zamani, Nader; Brown, Chester W (2011) Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. Endocr Rev 32:387-403
Bournat, Juan C; Brown, Chester W (2010) Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes 17:446-52
Shen, Joseph J; Huang, Lihua; Li, Liunan et al. (2009) Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose. Mol Endocrinol 23:113-23
Itman, Catherine; Small, Chris; Griswold, Michael et al. (2009) Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes. Dev Dyn 238:1688-700
Chen, Canhe; Ware, Stephanie M; Sato, Akira et al. (2006) The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development 133:319-29
Loveland, K L; Hogarth, C; Mendis, S et al. (2005) Drivers of germ cell maturation. Ann N Y Acad Sci 1061:173-82
Brown, Chester W; Li, Liunan; Houston-Hawkins, Dianne E et al. (2003) Activins are critical modulators of growth and survival. Mol Endocrinol 17:2404-17
Hwang, Sandy T; Shulman, Robert J (2002) Update on management and treatment of short gut. Clin Perinatol 29:181-94, vii
Chang, Hua; Brown, Chester W; Matzuk, Martin M (2002) Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23:787-823
Hwang, Sandy T; Urizar, Nancy L; Moore, David D et al. (2002) Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor. Gastroenterology 122:1483-92

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