UCLA School of Medicine has a long tradition of the application of knowledge gained through basic science research to the clinical setting to benefit the health of children. The Human and Molecular Development theme of the proposed UCLA Child Health Research Center (CHRC) emphasizes our fundamental approach to the diseases of children that includes the discipline of developmental biology, molecular genetics and cell biology. Each of the proposed CHRC Faculty Mentors is committed to training pediatrician scientists and each one is the Principal Investigator with ROI, PO1 and/or HHMI funding. All of the proposed Faculty Mentors can provide basic science training in methodology to allow junior pediatric faculty members to establish their own independent, fundable research programs applicable to the clinical problems of children. The objectives of the proposed UCLA CHRC include: 1)to increase the number, effectiveness, and gender and ethnic diversity of pediatric investigators engaged in human and molecular development research applied to child health problems by establishing a center of excellence to be known as the UCLA CHRC, by developing mentoring (including the Faculty Mentors, the CHRC Advisory Committee, external reviewers, and the Academic Pediatrics Course) and by the monthly research seminar; 2)to facilitate the research activities of New Program Development Awardees and Faculty Mentors by providing the Human and Molecular Development Core Laboratory; and 3)to provide increased opportunities for creative interdisciplinary approaches to pediatric diseases by bringing together basic scientists and pediatrician investigators interested in human and molecular development applications to clinical medicine through the use of the core laboratory and the monthly research seminars.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (SRC (CH))
Program Officer
Grave, Gilman D
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Equils, Ozlem; Salehi, Ken Khosrowdad; Cornataeanu, Randall et al. (2006) Repeated lipopolysaccharide (LPS) exposure inhibits HIV replication in primary human macrophages. Microbes Infect 8:2469-76
Zhang, Yao-Hua; Huang, Bing-Ling; Jialal, Ishwarlal et al. (2006) Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA. Pediatr Res 59:590-2
Equils, O; Naiki, Y; Shapiro, A M et al. (2006) 1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immunol 143:58-64
Equils, Ozlem; Singh, Sapna; Karaburun, Semra et al. (2005) Intra-uterine growth restriction downregulates the hepatic toll like receptor-4 expression and function. Clin Dev Immunol 12:59-66
Krejci, Pavel; Bryja, Vitezslav; Pachernik, Jiri et al. (2004) FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells. Exp Cell Res 297:152-64
Shim, Melanie L; Levitt Katz, Lorraine E; Davis, Jason et al. (2004) Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells. Growth Horm IGF Res 14:216-25
Zhang, Yao-Hua; Huang, Bing-Ling; Niakan, Kathy K et al. (2004) IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1. Hum Mutat 24:273
Clipsham, R; Niakan, K; McCabe, E R (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr Patterns 4:3-14
Equils, Ozlem; Madak, Zeynep; Liu, Chunrin et al. (2004) Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat. J Immunol 172:7642-6
Equils, Ozlem; Schito, Marco L; Karahashi, Hiase et al. (2003) Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: implications of simultaneous activation of TLRs on HIV replication. J Immunol 170:5159-64

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