Children's National Medical Center (CN) is submitting a competitive renewal for its Intellectual and Developmental Disabilities Research Center (IDDRC). The focus of this Center is on cellular, physiological and neurobehavioral aspects of brain development and dysfunction, and on the mechanisms of genetic diseases causing intellectual and other developmental disabilities. The Center comprises 151 NIH and other federally funded projects, with a total annual direct costs of more than $50 million, of which over $12 million is from NICHD. The projects that are part of the IDDRC cover 27 of the 31 areas of focus in the IDDRC RFA:HD-10-022. A total of 96 faculty members from 25 departments/divisions at the participating institutions (CN, GU, GWU, HU) are affiliated with the IDDRC as Center Investigators. We propose to support an Administrative Core (Administrative Core) and 5 scientific cores: Biostatistics and Informatics (Biostatistics and Informatics Core), Cellular Imaging (CIC), Proteomics and Genomics (PGC), Neuroimaging (NIC) and Neurobehavioral Evaluation (Neurobehavioral Evaluation Core). The Director of the IDDRC, Vittorio Gallo, Ph.D. is also Director of the Centerfor Neuroscience Research at CN, where he developed a research program on neurodevelopmental disorders. He will direct the Administrative Core that functions as the heart/coordinating core of the entire IDDRC. The Administrative Core will promote growth of the IDDRC by providing advocacy, management and administration, communication and training, compliance and quality assurance, strategic planning and recruitment. Biostatistics and Informatics Core provides a broad range of study design, information management, and statistical support services extending from the design of research studies to publication of results. CIC assists investigators with a broad array of imaging tools for cellular analysis, and provides advisory and training services. PGC provides advanced genomics and proteomics technologies, genetic counseling as well as specialized statistical analyses for DNA, mRNA and proteomics studies. NIC provides support for image acquisition, image sequence selection and implementation, paradigm design for functional studies, software development, image processing/analysis. Neurobehavioral Evaluation Core provides sophisticated neurobehavioral and neuropsychological research support to define developmental and behavioral phenotypes and to develop or validate new methods for this purpose. As demonstrated in the past funding cycle, the continued support to our IDDRC will further enhance recruitment of new IDD investigators, and will promote interdisciplinary IDDR to generate innovation, resulting in major advancements in IDDR.

Public Health Relevance

Intellectual and developmental disabilities (IDDs) affect 15% of children, but little is known of their neurological/neurobehavioral/genetic causes. Our IDD Research Center (IDDRC) includes multidisciplinary programs and supports investigators through unique, cost effective research Cores providing a broad range of current technologies. This research will improve our understanding of the causes underlying IDDs and develop innovative therapies, to permit each child to achieve full physical/intellectual potential.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD040677-14
Application #
8733071
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Parisi, Melissa
Project Start
2001-09-17
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20010
Morton, Paul D; Korotcova, Ludmila; Lewis, Bobbi K et al. (2017) Abnormal neurogenesis and cortical growth in congenital heart disease. Sci Transl Med 9:
Sanz, Jacqueline H; Berl, Madison M; Armour, Anna C et al. (2017) Prevalence and pattern of executive dysfunction in school age children with congenital heart disease. Congenit Heart Dis 12:202-209
Salka, Kyle; Bhuvanendran, Shivaprasad; Wilson, Kassandra et al. (2017) Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential for Endoplasmic Reticulum to Outer Mitochondrial Membrane Protein Transport. Sci Rep 7:16
Forbes, Thomas A; Gallo, Vittorio (2017) All Wrapped Up: Environmental Effects on Myelination. Trends Neurosci 40:572-587
Defour, Aurelia; Medikayala, Sushma; Van der Meulen, Jack H et al. (2017) Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle. Hum Mol Genet 26:1979-1991
Vila, Maria C; Rayavarapu, Sree; Hogarth, Marshall W et al. (2017) Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy. Cell Death Differ 24:330-342
Moler, Frank W; Silverstein, Faye S; Holubkov, Richard et al. (2017) Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med 376:318-329
Tague, Lauren; Donofrio, Mary T; Fulgium, Amanda et al. (2017) Common Findings in Late-Gestation Fetal Echocardiography. J Ultrasound Med 36:2431-2437
Al-Shargabi, T; Govindan, R B; Dave, R et al. (2017) Inflammatory cytokine response and reduced heart rate variability in newborns with hypoxic-ischemic encephalopathy. J Perinatol 37:668-672
Lischinsky, Julieta E; Sokolowski, Katie; Li, Peijun et al. (2017) Embryonic transcription factor expression in mice predicts medial amygdala neuronal identity and sex-specific responses to innate behavioral cues. Elife 6:

Showing the most recent 10 out of 324 publications