Abstract

The Molecular and Cellular Biology Core Center at the Texas Heart Institute is a multidisciplinary group of researchers focused on understanding the mechanisms of cardiovascular disease and applying that knowledge to developing innovative therapies. We are requesting startup funds for a newly independent investigator. Dr. Jun Wang, who will be joining our Core Center this summer. Dr. Wang's research program in the Core Center will focus on the role ofthe SUMO post-translational modification pathway in development of congenital heart diseases. THI is committed to providing Dr. Wang the resources and support necessary to build a successful research career, and in turn, Dr. Wang's experience and expertise will benefit other research groups in the Core Center and THI as a whole. The Molecular and Cellular Biology Core Center at the Texas Heart Institute is dedicated to understanding cardiovascular disease at a molecular level, and applying that knowledge to developing innovative therapies. Our newly independent investigator. Dr. Jun Wang, will study genetic and molecular aspects of congenital heart defects.

Public Health Relevance

The Molecular and Cellular Biology Core Center at the Texas Heart Institute is dedicated to understanding cardiovascular disease at a molecular level, and applying that knowledge to developing innovative therapies. Our newly independent investigator. Dr. Jun Wang, will study genetic and molecular aspects of congenital heart defects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Center Core Grants (P30)
Project #
5P30HL101336-02
Application #
7936124
Study Section
Special Emphasis Panel (ZHL1-CSR-E (O1))
Program Officer
Carlson, Drew E
Project Start
2009-09-30
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$531,285
Indirect Cost

  Institution

Name
Texas Heart Institute
Department
Type
DUNS #
086987831
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Kim, Eun Young; Zhang, Yi; Beketaev, Ilimbek et al. (2015) SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. J Mol Cell Cardiol 78:154-64
Kim, Eun Young; Zhang, Yi; Ye, Bo et al. (2015) Involvement of activated SUMO-2 conjugation in cardiomyopathy. Biochim Biophys Acta 1852:1388-99
Kim, Eun Young; Chen, Li; Ma, Yanlin et al. (2012) Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol 52:638-49
Wang, Jun (2011) Cardiac function and disease: emerging role of small ubiquitin-related modifier. Wiley Interdiscip Rev Syst Biol Med 3:446-57