The purpose of this proposal to establish an NHLBI Research Center at Howard University that will augment and Strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung and blood, and sleep diseases and disorders. The focus of the Center will be hemoglobinopathies, iron metabolism and oxygen-sensing, and It will build on and synergize with our existing NHLBI Research Scientist Program. From 1999 to 2010, the NHLBI Research Scientist Award at Howard University has facilitated the organization of a new research program that has contributed to the acquisition of 34 additional grants with total direct costs of over $29,000,000 and total Indirect costs of over $9,000,000. The program has been instrumental in bringing 11 new research faculty to Howard University. It has also provided research opportunities for 22 undergraduate students, 14 medical students, 7 masters level graduate students, 8 PhD candidates, 10 post-doctoral candidates, 19 residents and fellows, and 22 existing faculty members. Progress has been made in a variety of diseases that disproportionately affect minority populations, including severe malarial anemia, non-HFE iron overload, the influence of underlying hematologic conditions on HIV disease, and the pulmonary complications of sickle cell disease. The Award has resulted in 150 peer-reviewed publications. Building on this success, we now propose to establish an NHLBI Research Center at Howard University.
Aim 1. Establish an External Advisory Board of six external scientists who will advise the proposed NHLBI Research Center at Howard University leadership and provide an evaluation of the research program.
Aim 2. Recruit an additional established scientist who can complement and build upon our existing research program in hemglobinopathies, iron metabolism and oxygen sensing.
Aim 3. Expand and enhance the research advances made by the existing NHLBI Research Scientist Program at Howard University in clinical and molecular aspects of sickle cell disease, iron metabolism and oxygen sensing in African-Americans and other populations.

Public Health Relevance

The NHLBI Research Center at Howard University will augment and strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung, blood, and sleep diseases and disorders. The ultimate goal of this program is to increase a critical mass of well-trained scientists with active, funded laboratories at Howard University.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Center Core Grants (P30)
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Special Emphasis Panel (ZHL1-CSR-G (F1))
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Lee, Albert
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Howard University
Schools of Medicine
United States
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Zhang, Xu; Zhang, Wei; Ma, Shwu-Fan et al. (2014) Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis 52:35-45
Nekhai, Sergei; Kumari, Namita; Dhawan, Subhash (2013) Role of cellular iron and oxygen in the regulation of HIV-1 infection. Future Virol 8:301-311
Nekhai, Sergei; Xu, Min; Foster, Altreisha et al. (2013) Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin. Haematologica 98:455-63
Van Duyne, Rachel; Guendel, Irene; Jaworski, Elizabeth et al. (2013) Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription. J Mol Biol 425:812-29
Tomasic, Nikica Ljubas; Piterkova, Lucie; Huff, Chad et al. (2013) The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W). Haematologica 98:560-7