This application proposes the renewal for 2014-2019 of the Center for AIDS Intervention Research (CAIR) at the Medical College of Wisconsin as an HIV behavioral research Center. CAIR's thematic mission is the conceptualization, conduct, and rigorous evaluation of interventions to prevent HIV infection in communities most vulnerable to the disease;the development of interventions to improve health outcomes among persons living with the disease;and the rapid dissemination of research findings to both the scientific community and public health service provides. The Center's Core structure supports the efforts of an interdisciplinary team of HIV prevention investigators, and CAIR has been highly productive and a strong regional, national, and international resource in the areas of research, training, and service to the scientific and public health communities. CAIR Investigators have made distinguished scientific contributions in the development of HIV prevention interventions for high-incidence populations in the United States, Eastern Europe, and other regions of the world;have advanced the field's scientific knowledge of how to transfer scientific advances to benefit service providers nationally and internationally;and have undertaken vigorous lines of behavioral and social science, methodological, and cost-effectiveness research applied to HIV prevention. CAIR's specific aims during the renewal period are: 1) the development of behavioral, social, and structural interventions that will lead to wide scale public health implementation of recently-emerging biomedical HIV prevention strategies;2) establishing the effectiveness of multi-level HIV prevention interventions that combine potent behavioral, social, structural, and biomedical interventions to achieve greatest public health impact in reducing HIV incidence;3) reducing HIV-related health disparities;and 4) serving as a resource that rapidly transforms scientific advances into sustainable public health practice. To support continued excellence in these areas, we propose a structure that brings together interdisciplinary teams and provides resources from the following Cores: Administration Core (Center strategic planning and oversight);Developmental Core (preliminary studies, internal peer review, Center conferences and professional development);Qualitative Core (qualitative and social science support);Quantitative Core (central data management, analysis, and biostatistical consultation);Intervention and Dissemination Core (intervention trial support and technology exchange initiatives);International Core (facilitating international initiatives);and Impact Science Core HIV prevention economic, modeling, and impact analyses). Center Cores synergistically interact, provide added value, and support achievement of CAIR's research aims.

Public Health Relevance

REVELANCE: With a wide array of new prevention strategies now available, the field is at a pivotal point where, for the first time, it is possible to envision how to end th HIV epidemic. During its Center renewal period, CAIR's research will emphasize integrated prevention approaches that combine the most potent behavioral, social, structural, and biomedical modalities to achieve high public health impact by reducing HIV incidence within communities most affected by the disease.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Special Emphasis Panel (ZMH1-ERB-M (02))
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Gordon, Christopher M
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Medical College of Wisconsin
Schools of Medicine
United States
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Uusk├╝la, Anneli; Des Jarlais, Don C; Raag, Mait et al. (2015) Combined prevention for persons who inject drugs in the HIV epidemic in a transitional country: the case of Tallinn, Estonia. AIDS Care 27:105-11
Glasman, Laura R; Skinner, Donald; Bogart, Laura M et al. (2015) Do Assessments of HIV Risk Behaviors Change Behaviors and Prevention Intervention Efficacy? An Experimental Examination of the Influence of Type of Assessment and Risk Perceptions. Ann Behav Med 49:358-70
Mitchell, Jason W (2014) Between and within couple-level factors associated with gay male couples' investment in a sexual agreement. AIDS Behav 18:1454-65
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Dickson-Gomez, Julia; Owczarzak, Jill; St Lawrence, Janet et al. (2014) Beyond the ball: implications for HIV risk and prevention among the constructed families of African American men who have sex with men. AIDS Behav 18:2156-68
Mitchell, Jason W (2014) Aspects of gay male couples' sexual agreements vary by their relationship length. AIDS Care 26:1164-70

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