Over 60% of world's HIV-1 infected individuals are in sub-Saharan African nations. In particular Zambia has one of the highest rates of infection. As in many developing countries, the academic medical community in Zambia is not enviable, and due to limited funds, meaning the emphasis in training most often focuses on clinical medicine rather than on biomedical research. Consequently, little is done to significantly improve patient care and laboratory support services. Faculty at the University of Zambia's School of Medicine (UNZA) and the University Teaching Hospital (UTH), located in the country's capital of Lusaka, recognize that to address the problem in rising cases of AIDS-associated diseases, including AIDS associated mental disorders and neurological diseases, a common and coordinated training and research program in NeuroAIDS is needed. Without such a program, it will be extremely difficult to develop the research capacity and infrastructure necessary to truly impact the country's healthcare agenda and to position faculty to compete for future research funding so that they can fully and efficiently participate in future research initiatives in HIV-associate neurological diseases. In recognition of this, we have now added this International Core as a new Core for the CHAIN Center, where we will work with our colleagues in Zambia to address these important issues.

Public Health Relevance

In this Core we will institute a training and research program to study HIV-associated neurological diseases in Zambia. This proposed program is unique, teaming Zambian and U.S. researchers to address the emerging problems of neurological diseases in HIV-infected individuals in understudied regions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062261-13
Application #
8436269
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
13
Fiscal Year
2013
Total Cost
$103,802
Indirect Cost
Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Villeneuve, Lance M; Purnell, Phillip R; Stauch, Kelly L et al. (2016) HIV-1 transgenic rats display mitochondrial abnormalities consistent with abnormal energy generation and distribution. J Neurovirol :
Li, Weizhe; Tong, Hsin-I; Gorantla, Santhi et al. (2016) Neuropharmacologic Approaches to Restore the Brain's Microenvironment. J Neuroimmune Pharmacol 11:484-94
Singh, Dhirender; McMillan, JoEllyn; Hilaire, James et al. (2016) Development and characterization of a long-acting nanoformulated abacavir prodrug. Nanomedicine (Lond) 11:1913-27
Sajja, Balasrinivasa R; Bade, Aditya N; Zhou, Biyun et al. (2016) Generation and Disease Model Relevance of a Manganese Enhanced Magnetic Resonance Imaging-Based NOD/scid-IL-2Rγc(null) Mouse Brain Atlas. J Neuroimmune Pharmacol 11:133-41
Jaeger, Philipp A; Lucin, Kurt M; Britschgi, Markus et al. (2016) Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Mol Neurodegener 11:31
Bade, Aditya N; Gorantla, Santhi; Dash, Prasanta K et al. (2016) Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice. Mol Neurobiol 53:3286-97
Zhang, Gang; Guo, Dongwei; Dash, Prasanta K et al. (2016) The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine 12:109-22
Burns, Ariel; Ciborowski, Pawel (2016) Acute exposure to methamphetamine alters TLR9-mediated cytokine expression in human macrophage. Immunobiology 221:199-207
Yang, Lu; Yao, Honghong; Chen, Xufeng et al. (2016) Role of Sigma Receptor in Cocaine-Mediated Induction of Glial Fibrillary Acidic Protein: Implications for HAND. Mol Neurobiol 53:1329-42
Dong, Weiguo; Embury, Christine M; Lu, Yaman et al. (2016) The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation. J Neuroinflammation 13:184

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