The overall objective of the Neurobiology Core is to provide the NeuroAIDS community with a set of neuropathological methods and in vivo neurobiological resources that will enhance the analysis and discovery of the mechanisms of neurodegeneration associated with prolonged survival with HIV infection, from a comprehensive and dynamic perspective. During the previous period of funding we developed novel neuropathogy-based techniques to asses neurogenesis and neurodegeneration, and supported over 35 funded NeuroAIDS investigators. For the renewal we will provide: 1) an array of techniques to facilitate quantitative analysis of neuronal injury that will facilitate studies on HIV-mediated neuropathogenesis;2) technical assistance and consultation on state-of-the-art neuropathological approaches;3) support for preliminary studies that utilize neuropathology data;4) mentorship for students and junior faculty in neurobiology and neuropathology;5) Collaboration with the Coordinating Core to disseminate information on HlV-related neuropathology and 6) technical support and facilitation of international collaborations. In anticipation of current and future needs derived from such investigations, we will expand our studies to include new markers of neurodegeneration (e.g. autophagy) and detection of novel sets of HIV related neuropathology that have emerged as a result of aging (AB, TAU, a-synuclein, lysosomal markers) and other co-morbidities (HCV, methamphetamine). We will also assist investigators in the neuroAIDS field with the better characterization of the patterns of white matter damage, neuro-inflammation and blood brain barrier alterations in HIV patients, and we will provide support for studies of transcriptional and epigenetic dysregulation resulting from acute and chronic HIV infection in the CNS. Our ability to provide scientific and technical support for such studies will be strengthened by our ongoing collaborations with the other Center Cores. Collaborative capacity building in resource limited settings will help research into possibly altered HIV neuropathogenesis related to viral and host differences in international settings.
Despite advances in modern antiviral therapy, neurocognitive impairments persist and affect quality of life and everyday functioning, thus having public health significance. The Neurobiology Core will support research into the underlying mechanisms of these disabling conditions.
|Curley, Paul; Rajoli, Rajith K R; Moss, Darren M et al. (2017) Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation. Antimicrob Agents Chemother 61:|
|Wallace, Lindsay M K; Ferrara, Maria; Brothers, Thomas D et al. (2017) Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV. AIDS Res Hum Retroviruses 33:157-163|
|Saravanan, Shanmugam; Kausalya, Bagavathi; Gomathi, Selvamurthi et al. (2017) Etravirine and Rilpivirine Drug Resistance Among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India. AIDS Res Hum Retroviruses 33:567-574|
|Faytell, Marika P; Doyle, Katie L; Naar-King, Sylvie et al. (2017) Visualisation of future task performance improves naturalistic prospective memory for some younger adults living with HIV disease. Neuropsychol Rehabil 27:1142-1155|
|Sheppard, David P; Woods, Steven Paul; Doyle, Katie L et al. (2017) Random Number Generation in HIV Disease: Associations with Neuropsychological Functions and Activities of Daily Living. Arch Clin Neuropsychol 32:53-62|
|Ubaida-Mohien, Ceereena; Lamberty, Benjamin; Dickens, Alex M et al. (2017) Informatic interrogation of CSF proteomic profiles from HIV-infected subjects implicates acute phase and complement systems in shifting cognitive status. AIDS :|
|Osorio, Georgina; Hoenigl, Martin; Quartarolo, Jennifer et al. (2017) Evaluation of opt-out inpatient HIV screening at an urban teaching hospital. AIDS Care 29:1014-1018|
|Carlozzi, Noelle E; Tulsky, David S; Wolf, Timothy J et al. (2017) Construct validity of the NIH Toolbox Cognition Battery in individuals with stroke. Rehabil Psychol 62:443-454|
|Tierney, Savanna M; Sheppard, David P; Kordovski, Victoria M et al. (2017) A comparison of the sensitivity, stability, and reliability of three diagnostic schemes for HIV-associated neurocognitive disorders. J Neurovirol 23:404-421|
|Mehta, Sanjay R; Chaillon, Antoine; Gaines, Tommi L et al. (2017) Impact of Public Safety Policies on HIV Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis :|
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