The Neurovirology (NV) Core has the overall objective to support, through national and international collaboration and capacity-building, efforts at the genotypic identification and phenotypic characterization of HIV that is associated with neuroAIDS. Our scientific and service aims are to (1) identify the genotype of neuroadaptive HIV at varying stages of HIV-associated neurological disease;(2) to determine the phenotype of this neuroadaptive genotype;and (3) to develop methods for investigating viral dynamics and evolution within the CNS, especially in the setting of co-occurring conditions like other viral co-infections, bacterial translocation and HIV dual infection. Since viral populations in the CNS can be genetically distinct from populations in other tissues, such as blood, lymphoid and genital tract, appropriate virologic techniques will be needed to characterize neurotropism and neurovirulence in the CNS. The NV Core will enhance the HNRC's transdiciplinary aims through close collaboration with the Neurobehavioral, Neuromedical and Neurobiology Cores, utilizing multiple virologic techniques specific to CNS derived virus and its analysis. Considerable amounts of virologic data, specifically sequence data, will be generated through the research supported by this Core, including international collaborations. Management of these data will be aided through web-based systems, developed in cooperation with the Data Management and Information Systems Unit. Investigating the impact of HIV-associated neurological disease throughout the world will require the development of location-specific virologic capabilities and remote-access to analytical methods that have been validated for use in neuroAIDS investigations: these will be supported by the NV Core. Through existing (e.g., Brazil, India, Romania and China) and planned (e.g., Mexico, Ethiopia, and South Africa) collaborations, we will provide technical support in the development of molecular virology capabilities to address the specific research objectives of each locale. The NV Core, with its variety of cutting-edge molecular virologic techniques, is essential to fundamental advances in understanding the neuropathogenesis of HIV.

Public Health Relevance

HIV associated neurocognitive disorder (HAND) remains a significant problem among people infected with HIV throughout the world. As a component of the HIV Neurobehavioral Research Center, the Neurovirology Core will provide scientific expertise and technical support for virologic studies that address the neuropathogenesis of HIV with the ultimate goal of developing clinically relevant measures to interrupt the neurologic morbidity associated with HIV infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062512-12
Application #
8377611
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
12
Fiscal Year
2012
Total Cost
$124,199
Indirect Cost
$43,031
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Curley, Paul; Rajoli, Rajith K R; Moss, Darren M et al. (2017) Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation. Antimicrob Agents Chemother 61:
Wallace, Lindsay M K; Ferrara, Maria; Brothers, Thomas D et al. (2017) Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV. AIDS Res Hum Retroviruses 33:157-163
Saravanan, Shanmugam; Kausalya, Bagavathi; Gomathi, Selvamurthi et al. (2017) Etravirine and Rilpivirine Drug Resistance Among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India. AIDS Res Hum Retroviruses 33:567-574
Ubaida-Mohien, Ceereena; Lamberty, Benjamin; Dickens, Alex M et al. (2017) Informatic interrogation of CSF proteomic profiles from HIV-infected subjects implicates acute phase and complement systems in shifting cognitive status. AIDS :
Faytell, Marika P; Doyle, Katie L; Naar-King, Sylvie et al. (2017) Visualisation of future task performance improves naturalistic prospective memory for some younger adults living with HIV disease. Neuropsychol Rehabil 27:1142-1155
Sheppard, David P; Woods, Steven Paul; Doyle, Katie L et al. (2017) Random Number Generation in HIV Disease: Associations with Neuropsychological Functions and Activities of Daily Living. Arch Clin Neuropsychol 32:53-62
Tierney, Savanna M; Sheppard, David P; Kordovski, Victoria M et al. (2017) A comparison of the sensitivity, stability, and reliability of three diagnostic schemes for HIV-associated neurocognitive disorders. J Neurovirol 23:404-421
Osorio, Georgina; Hoenigl, Martin; Quartarolo, Jennifer et al. (2017) Evaluation of opt-out inpatient HIV screening at an urban teaching hospital. AIDS Care 29:1014-1018
Carlozzi, Noelle E; Tulsky, David S; Wolf, Timothy J et al. (2017) Construct validity of the NIH Toolbox Cognition Battery in individuals with stroke. Rehabil Psychol 62:443-454
Vesa, Jouni; Chaillon, Antoine; Wagner, Gabriel A et al. (2017) Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles. AIDS 31:1149-1158

Showing the most recent 10 out of 686 publications