This is a competing renewal of the UCSD HIV Neurobehavioral Research Center (HNRC), in response to PAR-08-009. The renewal builds on the track record of the HNRC as a national and international leader and resource facilitating research on neuropathogenesis, treatment, and prevention of HIV-associated neurocognitive disorders (HAND). In the renewal, our work will be guided by continuity of the major themes established in the prior period, and augmented by three areas of special concentration in the next 5 years. The continuity themes include: 1) delineating the attributes of the virus, host, and host-virus interaction that determine HAND;2) identifying mechanisms by which host-virus factors generate neural injury;3) understanding the role of comorbid factors;4) developing strategies to prevent or ameliorate HAND;5) determining the real life significance of HAND and its treatment. The areas of special emphasis will be 1) supporting studies examining the effects of aging on the prevalence, manifestations, mechanisms, and treatment of HAND;2) determining the incidence of HAND, its clinical and biological correlates, unique mechanisms, and possibility of prevention in the acute/early stages of HIV infection (i.e., in the first 6 months);and 3) implementing improved translation of research findings to the clinic. In terms of the latter, the HNRC envisions support of studies on better CNS penetrating ARVs, adjunctive neuroprotective therapies, improved biomarkers of HAND, and improved assessment methodologies derived from research experience. To accomplish these goals the HNRC will maintain 5 scientific Cores (Neuromedical, Neurobehavioral, Neurolmaging, Neurovirology, and Neurobiology) that will provide intellectual leadership and technical support, plus 3 over-arching cores to support and coordinate their activities: The Developmental Core will support innovative preliminary experiments and coordinate training and mentorship with the scientific cores and HNRC associated faculty, targeting the future generation of neuro-HIV scientists. The International Core will provide consultation to international scholars, translation of techniques developed at the HNRC to diverse settings around the world, and support joint research efforts between US and foreign investigators. The activities of the HNRC will be led by an Executive Team and synergized by a Coordinating Core consisting of Administrative, Participant Accrual and Retention, Data Management and Information Systems, and Statistics units. With these structures and processes the HNRC will continue to foster its national and international leadership role in neuro-HIV research, training, and treatment.

Public Health Relevance

Despite treatment advances, people with HIV infection often still develop neurologic problems. The HIV Neurobehavioral Research Center will provide scientific leadership and technical support for innovative studies that address the neuropathogenesis, continued persistence and treatment of HIV-associated neurocognitive disorders (HAND). Areas of special emphasis will include the effects of aging on HAND, the impact of early events on the future development of HAND, and improved translation of findings to the clinic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062512-13
Application #
8444506
Study Section
Special Emphasis Panel (ZMH1-ERB-M (03))
Program Officer
Joseph, Jeymohan
Project Start
2001-04-24
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
13
Fiscal Year
2013
Total Cost
$1,706,510
Indirect Cost
$601,973
Name
University of California San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Moore, David J; Pasipanodya, Elizabeth C; Umlauf, Anya et al. (2018) Individualized texting for adherence building (iTAB) for methamphetamine users living with HIV: A pilot randomized clinical trial. Drug Alcohol Depend 189:154-160
Babakhanyan, Ida; McKenna, Benjamin S; Casaletto, Kaitlin B et al. (2018) National Institutes of Health Toolbox Emotion Battery for English- and Spanish-speaking adults: normative data and factor-based summary scores. Patient Relat Outcome Meas 9:115-127
Hellmuth, Joanna; Milanini, Benedetta; Masliah, Eliezer et al. (2018) A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder. Neurocase 24:213-219
Hoenigl, Martin; Moser, Carlee; Funderburg, Nicholas et al. (2018) Soluble Urokinase Plasminogen Activator Receptor (suPAR) is predictive of Non-AIDS Events during Antiretroviral Therapy-mediated Viral Suppression. Clin Infect Dis :
MacDuffie, Katherine E; Brown, Gregory G; McKenna, Benjamin S et al. (2018) Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume. Neuroimage Clin 20:1044-1052
Lin, Timothy C; Dijkstra, Maartje; De Bree, Godelieve J et al. (2018) Brief Report: The Amsterdam Symptom and Risk-Based Score Predicts for Acute HIV Infection in Men Who Have Sex With Men in San Diego. J Acquir Immune Defic Syndr 79:e52-e55
Chow, Felicia C; Makanjuola, Akintomiwa; Wu, Kunling et al. (2018) Physical activity is associated with lower odds of cognitive impairment in women but not men living with HIV infection. J Infect Dis :
Sundermann, Erin E; Heaton, Robert K; Pasipanodya, Elizabeth et al. (2018) Sex differences in HIV-associated cognitive impairment: an observational cohort study. AIDS :
Namazi, Golnaz; Fajnzylber, Jesse M; Aga, Evgenia et al. (2018) The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies. J Infect Dis 218:1954-1963
Jumare, Jibreel; El-Kamary, Samer S; Magder, Laurence et al. (2018) Plasma HIV RNA level is associated with neurocognitive function among HIV-1-infected patients in Nigeria. J Neurovirol 24:712-719

Showing the most recent 10 out of 743 publications