This is a competing renewal of the UCSD HIV Neurobehavioral Research Center (HNRC), in response to PAR-08-009. The renewal builds on the track record of the HNRC as a national and international leader and resource facilitating research on neuropathogenesis, treatment, and prevention of HIV-associated neurocognitive disorders (HAND). In the renewal, our work will be guided by continuity of the major themes established in the prior period, and augmented by three areas of special concentration in the next 5 years. The continuity themes include: 1) delineating the attributes of the virus, host, and host-virus interaction that determine HAND;2) identifying mechanisms by which host-virus factors generate neural injury;3) understanding the role of comorbid factors;4) developing strategies to prevent or ameliorate HAND;5) determining the real life significance of HAND and its treatment. The areas of special emphasis will be 1) supporting studies examining the effects of aging on the prevalence, manifestations, mechanisms, and treatment of HAND;2) determining the incidence of HAND, its clinical and biological correlates, unique mechanisms, and possibility of prevention in the acute/early stages of HIV infection (i.e., in the first 6 months);and 3) implementing improved translation of research findings to the clinic. In terms of the latter, the HNRC envisions support of studies on better CNS penetrating ARVs, adjunctive neuroprotective therapies, improved biomarkers of HAND, and improved assessment methodologies derived from research experience. To accomplish these goals the HNRC will maintain 5 scientific Cores (Neuromedical, Neurobehavioral, Neurolmaging, Neurovirology, and Neurobiology) that will provide intellectual leadership and technical support, plus 3 over-arching cores to support and coordinate their activities: The Developmental Core will support innovative preliminary experiments and coordinate training and mentorship with the scientific cores and HNRC associated faculty, targeting the future generation of neuro-HIV scientists. The International Core will provide consultation to international scholars, translation of techniques developed at the HNRC to diverse settings around the world, and support joint research efforts between US and foreign investigators. The activities of the HNRC will be led by an Executive Team and synergized by a Coordinating Core consisting of Administrative, Participant Accrual and Retention, Data Management and Information Systems, and Statistics units. With these structures and processes the HNRC will continue to foster its national and international leadership role in neuro-HIV research, training, and treatment.
Despite treatment advances, people with HIV infection often still develop neurologic problems. The HIV Neurobehavioral Research Center will provide scientific leadership and technical support for innovative studies that address the neuropathogenesis, continued persistence and treatment of HIV-associated neurocognitive disorders (HAND). Areas of special emphasis will include the effects of aging on HAND, the impact of early events on the future development of HAND, and improved translation of findings to the clinic.
|Sadanand, Saheli; Das, Jishnu; Chung, Amy W et al. (2018) Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors. AIDS 32:443-450|
|Fields, Jerel Adam; Spencer, Brian; Swinton, Mary et al. (2018) Alterations in brain TREM2 and Amyloid-? levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem 147:784-802|
|de Almeida, Sérgio M; Tang, Bin; Ribeiro, Clea E et al. (2018) Neprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B. J Acquir Immune Defic Syndr 78:248-256|
|Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108|
|de Almeida, Sergio M; Oliveira, Michelli F; Chaillon, Antoine et al. (2018) Transient and asymptomatic meningitis in human immunodeficiency virus-1 subtype C: a case study of genetic compartmentalization and biomarker dynamics. J Neurovirol 24:786-796|
|Tierney, Savanna; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Semantic Memory in HIV-associated Neurocognitive Disorders: An Evaluation of the ""Cortical"" Versus ""Subcortical"" Hypothesis. Arch Clin Neuropsychol 33:406-416|
|Blixen, Carol; Sajatovic, Martha; Moore, David J et al. (2018) Patient Participation in the Development of a Customized M-Health Intervention to Improve Medication Adherence in Poorly Adherent Individuals with Bipolar Disorder (BD) and Hypertension (HTN). Int J Healthc 4:25-35|
|Patterson, Thomas L; Semple, Shirley J; Abramovitz, Daniela et al. (2018) Impact of time perspectives on texting intervention to reduce HIV/STI transmission among female sex workers in Tijuana and Ciudad Juarez, Mexico. J Behav Med :|
|Sheppard, David P; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Construct validity of the UCSD performance-based skills assessment-brief version (UPSA-B) in HIV disease. Appl Neuropsychol Adult 25:543-554|
|Jenks, Jeffrey D; Hoenigl, Martin (2018) Treatment of Aspergillosis. J Fungi (Basel) 4:|
Showing the most recent 10 out of 743 publications