The Neurovirology (NV) Core has the overall objective to support, through national and international collaboration and capacity-building, efforts at the genotypic identification and phenotypic characterization of HIV that is associated with neuroAIDS. Our scientific and service aims are to (1) identify the genotype of neuroadaptive HIV at varying stages of HIV-associated neurological disease;(2) to determine the phenotype of this neuroadaptive genotype;and (3) to develop methods for investigating viral dynamics and evolution within the CNS, especially in the setting of co-occurring conditions like other viral co-infections, bacterial translocation and HIV dual infection. Since viral populations in the CNS can be genetically distinct from populations in other tissues, such as blood, lymphoid and genital tract, appropriate virologic techniques will be needed to characterize neurotropism and neurovirulence in the CNS. The NV Core will enhance the HNRC's transdiciplinary aims through close collaboration with the Neurobehavioral, Neuromedical and Neurobiology Cores, utilizing multiple virologic techniques specific to CNS derived virus and its analysis. Considerable amounts of virologic data, specifically sequence data, will be generated through the research supported by this Core, including international collaborations. Management of these data will be aided through web-based systems, developed in cooperation with the Data Management and Information Systems Unit. Investigating the impact of HIV-associated neurological disease throughout the world will require the development of location-specific virologic capabilities and remote-access to analytical methods that have been validated for use in neuroAIDS investigations: these will be supported by the NV Core. Through existing (e.g., Brazil, India, Romania and China) and planned (e.g., Mexico, Ethiopia, and South Africa) collaborations, we will provide technical support in the development of molecular virology capabilities to address the specific research objectives of each locale. The NV Core, with its variety of cutting-edge molecular virologic techniques, is essential to fundamental advances in understanding the neuropathogenesis of HIV.

Public Health Relevance

HIV associated neurocognitive disorder (HAND) remains a significant problem among people infected with HIV throughout the world. As a component of the HIV Neurobehavioral Research Center, the Neurovirology Core will provide scientific expertise and technical support for virologic studies that address the neuropathogenesis of HIV with the ultimate goal of developing clinically relevant measures to interrupt the neurologic morbidity associated with HIV infection.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
La Jolla
United States
Zip Code
Heaton, Robert K; Franklin Jr, Donald R; Deutsch, Reena et al. (2015) Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis 60:473-80
Hobkirk, Andréa L; Starosta, Amy J; De Leo, Joseph A et al. (2015) Psychometric validation of the BDI-II among HIV-positive CHARTER study participants. Psychol Assess 27:457-66
Morgan, Erin E; Iudicello, Jennifer E; Cattie, Jordan E et al. (2015) Neurocognitive impairment is associated with lower health literacy among persons living with HIV infection. AIDS Behav 19:166-77
Casaletto, K B; Obermeit, L; Morgan, E E et al. (2015) Depression and executive dysfunction contribute to a metamemory deficit among individuals with methamphetamine use disorders. Addict Behav 40:45-50
Repunte-Canonigo, Vez; Lefebvre, Celine; George, Olivier et al. (2014) Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener 9:26
Fazeli, Pariya L; Woods, Steven Paul; Heaton, Robert K et al. (2014) An active lifestyle is associated with better neurocognitive functioning in adults living with HIV infection. J Neurovirol 20:233-42
Andrade, Rosa M; Torriani, Francesca J; Ellis, Ronald J (2014) Acute HIV infection presenting as fulminant meningoencephalitis with massive CSF viral replication. Neurol Clin Pract 4:256-259
Orlov, Marika; Vaida, Florin; Williamson, Kathryn et al. (2014) Antigen-presenting phagocytic cells ingest malaria parasites and increase HIV replication in a tumor necrosis factor ?-dependent manner. J Infect Dis 210:1562-72
Overk, Cassia R; Masliah, Eliezer (2014) Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol 88:508-16
Akolo, Christopher; Royal 3rd, Walter; Cherner, Mariana et al. (2014) Neurocognitive impairment associated with predominantly early stage HIV infection in Abuja, Nigeria. J Neurovirol 20:380-7

Showing the most recent 10 out of 313 publications