The Neurovirology (NV) Core has the overall objective to support, through national and international collaboration and capacity-building, efforts at the genotypic identification and phenotypic characterization of HIV that is associated with neuroAIDS. Our scientific and service aims are to (1) identify the genotype of neuroadaptive HIV at varying stages of HIV-associated neurological disease;(2) to determine the phenotype of this neuroadaptive genotype;and (3) to develop methods for investigating viral dynamics and evolution within the CNS, especially in the setting of co-occurring conditions like other viral co-infections, bacterial translocation and HIV dual infection. Since viral populations in the CNS can be genetically distinct from populations in other tissues, such as blood, lymphoid and genital tract, appropriate virologic techniques will be needed to characterize neurotropism and neurovirulence in the CNS. The NV Core will enhance the HNRC's transdiciplinary aims through close collaboration with the Neurobehavioral, Neuromedical and Neurobiology Cores, utilizing multiple virologic techniques specific to CNS derived virus and its analysis. Considerable amounts of virologic data, specifically sequence data, will be generated through the research supported by this Core, including international collaborations. Management of these data will be aided through web-based systems, developed in cooperation with the Data Management and Information Systems Unit. Investigating the impact of HIV-associated neurological disease throughout the world will require the development of location-specific virologic capabilities and remote-access to analytical methods that have been validated for use in neuroAIDS investigations: these will be supported by the NV Core. Through existing (e.g., Brazil, India, Romania and China) and planned (e.g., Mexico, Ethiopia, and South Africa) collaborations, we will provide technical support in the development of molecular virology capabilities to address the specific research objectives of each locale. The NV Core, with its variety of cutting-edge molecular virologic techniques, is essential to fundamental advances in understanding the neuropathogenesis of HIV.
HIV associated neurocognitive disorder (HAND) remains a significant problem among people infected with HIV throughout the world. As a component of the HIV Neurobehavioral Research Center, the Neurovirology Core will provide scientific expertise and technical support for virologic studies that address the neuropathogenesis of HIV with the ultimate goal of developing clinically relevant measures to interrupt the neurologic morbidity associated with HIV infection.
|Avci, G; Loft, S; Sheppard, D P et al. (2016) The effects of HIV disease and older age on laboratory-based, naturalistic, and self-perceived symptoms of prospective memory: does retrieval cue type and delay interval matter? Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 23:716-43|
|Spies, Georgina; Ahmed-Leitao, Fatima; Fennema-Notestine, Christine et al. (2016) Effects of HIV and childhood trauma on brain morphometry and neurocognitive function. J Neurovirol 22:149-58|
|Hestad, Knut A; Menon, J Anitha; Serpell, Robert et al. (2016) Do neuropsychological test norms from African Americans in the United States generalize to a Zambian population? Psychol Assess 28:18-38|
|Chin, Bum Sik; Chaillon, Antoine; Mehta, Sanjay R et al. (2016) Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol 88:1832-5|
|Royal 3rd, Walter; Cherner, Mariana; Burdo, Tricia H et al. (2016) Associations between Cognition, Gender and Monocyte Activation among HIV Infected Individuals in Nigeria. PLoS One 11:e0147182|
|Ellis, Ronald; Letendre, Scott L (2016) Update and New Directions in Therapeutics for Neurological Complications of HIV Infections. Neurotherapeutics 13:471-6|
|Sheppard, David P; Weber, Erica; Casaletto, Kaitlin B et al. (2016) Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults. J Assoc Nurses AIDS Care 27:595-607|
|Panichsillapakit, Theppharit; Smith, Davey M; Wertheim, Joel O et al. (2016) Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013. J Acquir Immune Defic Syndr 71:228-36|
|Var, Susanna R; Day, Tyler R C; Vitomirov, Andrej et al. (2016) Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. AIDS 30:839-48|
|Gianella, Sara; Kosakovsky Pond, Sergei L; Oliveira, Michelli F et al. (2016) Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy. Virus Evol 2:vew020|
Showing the most recent 10 out of 598 publications