The HNRC has expanded its international focus in recognition of opportunities for incremental knowldge of the neuropathology of HIV that can be addressed uniquely in resource-limited settings (RLS). The pertinent scientific topics include effects of viral and host genetic and mitochondrial factors;availability, efficacy, and timing of antiviral treatments;region-specific cofactors (e.g., exposure to co-infecting pathogens, specific drugs of abuse, trauma);and how sociocultural and environment differences affect the epidemiology, phenomenology, pathogenesis, and effectiveness of treatment for of neuroAIDS. Methodological issues include development of valid assessments of neurocognitive and daily functioning for use in diverse linguistic and cultural settings and in illiterate or semiliterate persons, as well as adaptation of neuromedical ascertainment methods for successful deployment in RLS. The International Core proposes to identify opportunities for international research and to facilitate partnering between HNRC investigators and scientist-clinicians in RLS in order to build capacity to undertake neuroAIDS research that is in line with HNRC scientific themes, and that is responsive to the needs and circumstances of those settings. The Core has coordinated scientific consultation, mentoring, training, and technical assistance designed to develop collaborative, investigator-initiated, fundable international research programs on NeuroAIDS. We have secured an NIH U-13 grant for 3 international NeuroAIDs training meetings and created the International Consortium of NeuroAIDS Scientists to maintain contact among investigators between meetings. During the last funding period, the International Core supported (1) baseline and multiple follow-up evaluations for an R- 01 study of HIV neurocognitive complications in two risk groups in China, (2) an R-21 study of perinatally infected Romanian adolescents, (3) an R21 study of NeuroAIDS in Brazil, (4) an R01 study of neurocognitive impairment after antiviral treatment initiation in Pune, India, and (5) an R01 study of effects of viral clade on neuroAIDS in four of the above sites and the US, as well as a number of smaller developmental projects. The International Core website consolidates information and facilitates access to resources. Our programs of on-site training and developmental grants for international colleagues (in coordination with Developmental Core) have promoted multiple developmental studies, and our communications and data management capacity has assisted investigators at several collaborating international sites.

Public Health Relevance

Most of the burden of HIV disease and associated neurocognitive disorder falls outside the U.S. The International Core is designed to further the scientific and resource aims of the HNRC by identifying and facilitating unique opportunities for international research that will lead to incremental advances in knowledge of the neuropathology of HIV and its possible treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062512-13
Application #
8444515
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
13
Fiscal Year
2013
Total Cost
$50,117
Indirect Cost
$17,678
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hestad, Knut A; Menon, J Anitha; Serpell, Robert et al. (2016) Do neuropsychological test norms from African Americans in the United States generalize to a Zambian population? Psychol Assess 28:18-38
Avci, G; Loft, S; Sheppard, D P et al. (2016) The effects of HIV disease and older age on laboratory-based, naturalistic, and self-perceived symptoms of prospective memory: does retrieval cue type and delay interval matter? Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 23:716-43
Spies, Georgina; Ahmed-Leitao, Fatima; Fennema-Notestine, Christine et al. (2016) Effects of HIV and childhood trauma on brain morphometry and neurocognitive function. J Neurovirol 22:149-58
Ellis, Ronald; Letendre, Scott L (2016) Update and New Directions in Therapeutics for Neurological Complications of HIV Infections. Neurotherapeutics 13:471-6
Chin, Bum Sik; Chaillon, Antoine; Mehta, Sanjay R et al. (2016) Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals. J Med Virol 88:1832-5
Royal 3rd, Walter; Cherner, Mariana; Burdo, Tricia H et al. (2016) Associations between Cognition, Gender and Monocyte Activation among HIV Infected Individuals in Nigeria. PLoS One 11:e0147182
Sheppard, David P; Weber, Erica; Casaletto, Kaitlin B et al. (2016) Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults. J Assoc Nurses AIDS Care 27:595-607
Panichsillapakit, Theppharit; Smith, Davey M; Wertheim, Joel O et al. (2016) Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013. J Acquir Immune Defic Syndr 71:228-36
Var, Susanna R; Day, Tyler R C; Vitomirov, Andrej et al. (2016) Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. AIDS 30:839-48
Gianella, Sara; Kosakovsky Pond, Sergei L; Oliveira, Michelli F et al. (2016) Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy. Virus Evol 2:vew020

Showing the most recent 10 out of 598 publications