The Developmental Core (DC) will aim to support innovative pilot research in domestic and international settings to foster the academic careers of new investigators in neuroAIDS research by capitalizing on UCSD's unique training environment and opportunities; and to support refinement of neuroAIDS hypotheses and methods, resulting in better understanding of pathogenesis and treatment of HIV in the central nervous system (CNS). The DC will accomplish these aims via two programs, the Developmental Grant Program and the Mentored Investigator Program (MIP), and by active linkage to other training and pilot programs associated with UCSD's AIDS Research Institute. In the current funding cycle, the DC awarded 9 developmental grants to junior researchers and junior faculty. In addition, the DC provided training in neuroAIDS research methods to 176 new or junior researchers, including 82 who completed the MIP. For the renewal we have reorganized the DC by fusing the most successful elements of two prior cores, namely Developmental and International, into a single, streamlined Developmental Core that includes both domestic and international training aims. To be maximally attentive to HNRC translational renewal themes Dr. Scott Letendre becomes the new Core Co-Director, assisted by Co-Director Dr. Allen McCutchan, leader of the former International Core. The Core will continue to emphasize performance of impactful, interdisciplinary, and translational neuroAIDS research that responds to the Office of AIDS Research (OAR) priorities. The Core will also work with the Administrative Core, the HNRC Scientific Core Directors, and the UCSD CFAR to incorporate new elements, including training in grant application preparation, a mock Study Section to review first project applications for new investigators (including career developmental awards), and a request-for-applications clearinghouse to focus trainees and mentors on the greatest needs of the NIH. The DC will also work closely with three training programs at UCSD, the NIMH R25 program, ?Interdisciplinary Research Fellowship in NeuroAIDS? (IRFN), the NIDA T32 program, ?Training in Research on Addictions in Interdisciplinary NeuroAIDS? (TRAIN), and the graduate program, ?Clinical Research Enhancement through Supplemental Training? (CREST).

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California, San Diego
La Jolla
United States
Zip Code
Sadanand, Saheli; Das, Jishnu; Chung, Amy W et al. (2018) Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors. AIDS 32:443-450
Fields, Jerel Adam; Spencer, Brian; Swinton, Mary et al. (2018) Alterations in brain TREM2 and Amyloid-? levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem 147:784-802
de Almeida, Sérgio M; Tang, Bin; Ribeiro, Clea E et al. (2018) Neprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B. J Acquir Immune Defic Syndr 78:248-256
Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108
de Almeida, Sergio M; Oliveira, Michelli F; Chaillon, Antoine et al. (2018) Transient and asymptomatic meningitis in human immunodeficiency virus-1 subtype C: a case study of genetic compartmentalization and biomarker dynamics. J Neurovirol 24:786-796
Tierney, Savanna; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Semantic Memory in HIV-associated Neurocognitive Disorders: An Evaluation of the ""Cortical"" Versus ""Subcortical"" Hypothesis. Arch Clin Neuropsychol 33:406-416
Blixen, Carol; Sajatovic, Martha; Moore, David J et al. (2018) Patient Participation in the Development of a Customized M-Health Intervention to Improve Medication Adherence in Poorly Adherent Individuals with Bipolar Disorder (BD) and Hypertension (HTN). Int J Healthc 4:25-35
Patterson, Thomas L; Semple, Shirley J; Abramovitz, Daniela et al. (2018) Impact of time perspectives on texting intervention to reduce HIV/STI transmission among female sex workers in Tijuana and Ciudad Juarez, Mexico. J Behav Med :
Sheppard, David P; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Construct validity of the UCSD performance-based skills assessment-brief version (UPSA-B) in HIV disease. Appl Neuropsychol Adult 25:543-554
Jenks, Jeffrey D; Hoenigl, Martin (2018) Treatment of Aspergillosis. J Fungi (Basel) 4:

Showing the most recent 10 out of 743 publications