The overall NeuroGerm (NG) Core is co-directed by Drs. Davey Smith and Rob Knight and comprises a ?Virology-Inflammation Unit? and a ?Microbiome Unit?. These units will be integral to the HIV Neurobehavioral Research Center (HNRC), and will develop new knowledge and new technologies to meet the Center's scientific and training goals. Specifically, the units will provide HNRC and collaborating researchers with expertise and techniques relevant to the virologic and immunologic investigation of HIV-associated neurocognitive disorder (HAND) with an enhanced focus on the role of the microbiome, and on HIV eradication from the central nervous system (CNS). The NG Core will offer a range of services focused on: (i) assay development, validation and provision, (ii) analytical support, (iii) quality assurance, (iv) training, and (v) provision of samples and reagents. Since viral populations in the central nervous system (CNS) can be genetically distinct from populations in other tissues, such as blood, lymphoid and genital tract, advanced virologic techniques will be needed to characterize neurotropism and neurovirulence in the CNS in relation to HAND, as well as to design appropriate HIV eradication strategies involving the CNS. The NG Core will also enhance the HNRC's transdiciplinary focus through close collaboration with the NeuroBiology, NeuroAssessment and Developmental Cores, utilizing multiple laboratory and analytical techniques specific to CNS derived virus, and characterizing the microbiome in relation to neurocognitive functioning. In summary, the NG Core will provide the proposed quality services to tackle the mission of the HNRC. The provision of these services will be based on a detailed strategic planning process designed to maintain flexibility and to maximize utility of offered services based on the scientific needs of the field and our associated HIV investigators. With its variety of cutting-edge molecular and immunologic techniques, the NG core will be crucial to the understanding and mechanisms of the neuropathogenesis of HIV.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California, San Diego
La Jolla
United States
Zip Code
Curley, Paul; Rajoli, Rajith K R; Moss, Darren M et al. (2017) Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation. Antimicrob Agents Chemother 61:
Wallace, Lindsay M K; Ferrara, Maria; Brothers, Thomas D et al. (2017) Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV. AIDS Res Hum Retroviruses 33:157-163
Saravanan, Shanmugam; Kausalya, Bagavathi; Gomathi, Selvamurthi et al. (2017) Etravirine and Rilpivirine Drug Resistance Among HIV-1 Subtype C Infected Children Failing Non-Nucleoside Reverse Transcriptase Inhibitor-Based Regimens in South India. AIDS Res Hum Retroviruses 33:567-574
Faytell, Marika P; Doyle, Katie L; Naar-King, Sylvie et al. (2017) Visualisation of future task performance improves naturalistic prospective memory for some younger adults living with HIV disease. Neuropsychol Rehabil 27:1142-1155
Sheppard, David P; Woods, Steven Paul; Doyle, Katie L et al. (2017) Random Number Generation in HIV Disease: Associations with Neuropsychological Functions and Activities of Daily Living. Arch Clin Neuropsychol 32:53-62
Ubaida-Mohien, Ceereena; Lamberty, Benjamin; Dickens, Alex M et al. (2017) Informatic interrogation of CSF proteomic profiles from HIV-infected subjects implicates acute phase and complement systems in shifting cognitive status. AIDS :
Osorio, Georgina; Hoenigl, Martin; Quartarolo, Jennifer et al. (2017) Evaluation of opt-out inpatient HIV screening at an urban teaching hospital. AIDS Care 29:1014-1018
Carlozzi, Noelle E; Tulsky, David S; Wolf, Timothy J et al. (2017) Construct validity of the NIH Toolbox Cognition Battery in individuals with stroke. Rehabil Psychol 62:443-454
Tierney, Savanna M; Sheppard, David P; Kordovski, Victoria M et al. (2017) A comparison of the sensitivity, stability, and reliability of three diagnostic schemes for HIV-associated neurocognitive disorders. J Neurovirol 23:404-421
Mehta, Sanjay R; Chaillon, Antoine; Gaines, Tommi L et al. (2017) Impact of Public Safety Policies on HIV Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis :

Showing the most recent 10 out of 686 publications