The overall NeuroGerm (NG) Core is co-directed by Drs. Davey Smith and Rob Knight and comprises a ?Virology-Inflammation Unit? and a ?Microbiome Unit?. These units will be integral to the HIV Neurobehavioral Research Center (HNRC), and will develop new knowledge and new technologies to meet the Center's scientific and training goals. Specifically, the units will provide HNRC and collaborating researchers with expertise and techniques relevant to the virologic and immunologic investigation of HIV-associated neurocognitive disorder (HAND) with an enhanced focus on the role of the microbiome, and on HIV eradication from the central nervous system (CNS). The NG Core will offer a range of services focused on: (i) assay development, validation and provision, (ii) analytical support, (iii) quality assurance, (iv) training, and (v) provision of samples and reagents. Since viral populations in the central nervous system (CNS) can be genetically distinct from populations in other tissues, such as blood, lymphoid and genital tract, advanced virologic techniques will be needed to characterize neurotropism and neurovirulence in the CNS in relation to HAND, as well as to design appropriate HIV eradication strategies involving the CNS. The NG Core will also enhance the HNRC's transdiciplinary focus through close collaboration with the NeuroBiology, NeuroAssessment and Developmental Cores, utilizing multiple laboratory and analytical techniques specific to CNS derived virus, and characterizing the microbiome in relation to neurocognitive functioning. In summary, the NG Core will provide the proposed quality services to tackle the mission of the HNRC. The provision of these services will be based on a detailed strategic planning process designed to maintain flexibility and to maximize utility of offered services based on the scientific needs of the field and our associated HIV investigators. With its variety of cutting-edge molecular and immunologic techniques, the NG core will be crucial to the understanding and mechanisms of the neuropathogenesis of HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062512-18
Application #
9438572
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sadanand, Saheli; Das, Jishnu; Chung, Amy W et al. (2018) Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors. AIDS 32:443-450
Fields, Jerel Adam; Spencer, Brian; Swinton, Mary et al. (2018) Alterations in brain TREM2 and Amyloid-? levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem 147:784-802
de Almeida, Sérgio M; Tang, Bin; Ribeiro, Clea E et al. (2018) Neprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B. J Acquir Immune Defic Syndr 78:248-256
Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108
de Almeida, Sergio M; Oliveira, Michelli F; Chaillon, Antoine et al. (2018) Transient and asymptomatic meningitis in human immunodeficiency virus-1 subtype C: a case study of genetic compartmentalization and biomarker dynamics. J Neurovirol 24:786-796
Tierney, Savanna; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Semantic Memory in HIV-associated Neurocognitive Disorders: An Evaluation of the ""Cortical"" Versus ""Subcortical"" Hypothesis. Arch Clin Neuropsychol 33:406-416
Blixen, Carol; Sajatovic, Martha; Moore, David J et al. (2018) Patient Participation in the Development of a Customized M-Health Intervention to Improve Medication Adherence in Poorly Adherent Individuals with Bipolar Disorder (BD) and Hypertension (HTN). Int J Healthc 4:25-35
Patterson, Thomas L; Semple, Shirley J; Abramovitz, Daniela et al. (2018) Impact of time perspectives on texting intervention to reduce HIV/STI transmission among female sex workers in Tijuana and Ciudad Juarez, Mexico. J Behav Med :
Sheppard, David P; Woods, Steven Paul; Verduzco, Marizela et al. (2018) Construct validity of the UCSD performance-based skills assessment-brief version (UPSA-B) in HIV disease. Appl Neuropsychol Adult 25:543-554
Jenks, Jeffrey D; Hoenigl, Martin (2018) Treatment of Aspergillosis. J Fungi (Basel) 4:

Showing the most recent 10 out of 743 publications