The newly reorganized, streamlined NeuroAssessment Core (NAC) will have the overall goal of supporting comprehensive neuromedical, neurobehavioral and neuroimaging assessments for the characterization of HIV+ individuals and HIV- controls in HNRC-affiliated studies. The Core will comprise 3 integrated subunits: Neuromedical (NM), Neurobehavioral (NBh) and Neuroimaging (NI).
We aim to facilitate and enhance multidisciplinary research in neuroAIDS by providing a range of services, training and scientific consultation to projects such as investigator-driven R01s and R21s, international neuroAIDS studies, and a variety of intra- and extramural investigations. Historically the Core and its investigators have been leaders in the field, spurring the development of new methods and adapting to the continually evolving scientific landscape. Consistent with this, the Core will provide resources to support the Center's new themes of HIV persistence and cure, and how the human gut microbiome interacts with HIV and its treatment to affect the CNS. Specific services relevant to HIV persistence and cure include serial lumbar punctures to evaluate viral rebound following HIV reservoir interventions, and high volume CSF collection and neurocognitive (NC) testing to assess effects of such interventions on brain functioning. The gut microbiome will be characterized by collecting and processing samples of stool. Standard evaluations will continue to include a structured neuromedical history, clinical and laboratory examinations, and establishment of diagnoses of central and peripheral neurological complications of HIV. The NAC's NI Unit will provide resources, including training, consultation, and technical support, for the detection and measurement of HIV- related brain injury using a broad array of techniques, including structural, functional, and metabolite MRI and PET imaging. This work will support investigations of the cognitive consequences and neuromedical correlates of these effects; the underlying pathological mechanisms that give rise to this damage; and potential biomarkers for treatment success. The NBh Unit will perform a comprehensive assessment of all participants in the HNRC cohort that will include well-validated measures of NC functioning, psychiatric status, and everyday functioning, in accordance with the HAND diagnostic guidelines. The NBh Unit's specific Resource Objectives are to provide: 1) demographically-adjusted individual, domain, and global summary scores of NC functioning; 2) Determinations of NC change in individual participants using reliable and validated actuarial methods; 3) Self-assessment and laboratory-based measures of everyday functioning; 4) Current and lifetime history of mood and substance use diagnoses; and 5) Technical assistance, training, certification, consultation, and career development mentoring. Data generated by the NAC range from NC performance and diagnostic formulations to ART information, disease staging and viral loads (VLs), to clinical laboratory measurements, medical histories, and physical examinations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062512-19
Application #
9638590
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2019-04-17
Budget End
2020-02-29
Support Year
19
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Marquine, María J; Flores, Ilse; Kamat, Rujvi et al. (2018) A composite of multisystem injury and neurocognitive impairment in HIV infection: association with everyday functioning. J Neurovirol 24:549-556
Jumare, Jibreel; Ndembi, Nicaise; El-Kamary, Samer S et al. (2018) Cognitive Function Among Antiretroviral Treatment-Naive Individuals Infected With Human Immunodeficiency Virus Type 1 Subtype G Versus CRF02_AG in Nigeria. Clin Infect Dis 66:1448-1453
Mukerji, Shibani S; Misra, Vikas; Lorenz, David R et al. (2018) Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1-Infected Adults in the United States. Clin Infect Dis 67:1182-1190
Marquine, María J; Heaton, Anne; Johnson, Neco et al. (2018) Differences in Neurocognitive Impairment Among HIV-Infected Latinos in the United States. J Int Neuropsychol Soc 24:163-175
Gianella, Sara; Sonya Haw, J; Blumenthal, Jill et al. (2018) The Importance of Human Immunodeficiency Virus Research for Transgender and Gender-Nonbinary Individuals. Clin Infect Dis 66:1460-1466
Patt, Virginie M; Brown, Gregory G; Thomas, Michael L et al. (2018) Factor Analysis of an Expanded Halstead-Reitan Battery and the Structure of Neurocognition. Arch Clin Neuropsychol 33:79-101
Kesby, James P; Chang, Ariel; Markou, Athina et al. (2018) Modeling human methamphetamine use patterns in mice: chronic and binge methamphetamine exposure, reward function and neurochemistry. Addict Biol 23:206-218
Morgan, Erin E; Woods, Steven Paul; Iudicello, Jennifer E et al. (2018) Poor Self-efficacy for Healthcare Provider Interactions Among Individuals with HIV-Associated Neurocognitive Disorders. J Clin Psychol Med Settings :
Faytell, Marika Pers; Doyle, Katie; Naar-King, Sylvie et al. (2018) Calendaring and alarms can improve naturalistic time-based prospective memory for youth infected with HIV. Neuropsychol Rehabil 28:1038-1051
Mehta, Sanjay R; Chaillon, Antoine; Gaines, Tommi L et al. (2018) Impact of Public Safety Policies on Human Immunodeficiency Virus Transmission Dynamics in Tijuana, Mexico. Clin Infect Dis 66:758-764

Showing the most recent 10 out of 743 publications