HIV-associated cognitive disorders remain prevalent, even among HIV positive individuals who receive highly active anti-retroviral treatments. There is a wealth of HIV-related neuroscience research at Johns Hopkins University (JHU), especially focused on oxidative stress as a critical pathogenic mechanism for neurological damage. Despite this rich environment, no definitive therapeutics for HIV-associated cognitive disorders have yet been developed. There is also an unfilled need to develop surrogate markers and more robust and simpler screening instruments for neurological diseases, which could eventually be used in resource-limited areas or by non-neurologists. Potential collaborations at Johns Hopkins are currently limited by the lack of a central organizing structure for this type of research and resources to facilitate cross-disciplinary and translational research. The JHU NIMH Center will address these needs to provide a resource to catalyze interdisciplinary research in HIV neuroscience. The goals of the JHU NIMH Center are to: 1. To facilitate collaborative research in HIV-related neuroscience with the goal of developing a definitive therapy for HIV-associated cognitive disorders based on targeting oxidative stress pathways. 2. To increase resources for HIV-related neuroscience research at JHU and to enhance the productivity of HIV-related neuroscience research locally, nationally and internationally. 3. To encourage high-risk, innovative developmental research in Neuro-AIDS, especially of a cross disciplinary nature. 4. To provide resources to encourage new investigators locally, nationally, and internationally to enter the field of HIV Neuro-AIDS research by providing educational and skill-developing resources for investigators to improve their expertise in detecting and treating HIV-related neurological complications. 5. To use focused throughput screening, using in vitro models to identify novel compounds useful for treatment of HIV-associated cognitive dysfunction with the over-arching theme of oxidative stress. 6. To identify and validate surrogate biomarkers based on proteomics and lipidomics[PSB1].

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH075673-05
Application #
7845500
Study Section
Special Emphasis Panel (ZMH1-ERB-N (07))
Program Officer
Joseph, Jeymohan
Project Start
2006-06-16
Project End
2011-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
5
Fiscal Year
2010
Total Cost
$1,288,239
Indirect Cost
Name
Johns Hopkins University
Department
Neurology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Raman, Mekala R; Tosakulwong, Nirubol; Zuk, Samantha M et al. (2017) Influence of preeclampsia and late-life hypertension on MRI measures of cortical atrophy. J Hypertens 35:2479-2485
Sacktor, Ned; Skolasky, Richard L; Moxley, Richard et al. (2017) Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial. J Neurovirol :
Ubaida-Mohien, Ceereena; Lamberty, Benjamin; Dickens, Alex M et al. (2017) Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients. AIDS 31:1365-1378
Figuera-Losada, Mariana; Thomas, Ajit G; Stathis, Marigo et al. (2017) Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs. Biochem Biophys Rep 9:266-272
Kronemer, Sharif I; Mandel, Jordan A; Sacktor, Ned C et al. (2017) Impairments of Motor Function While Multitasking in HIV. Front Hum Neurosci 11:212
Nedelcovych, Michael T; Manning, Arena A; Semenova, Svetlana et al. (2017) The Psychiatric Impact of HIV. ACS Chem Neurosci 8:1432-1434
Croteau, Joshua D; Engle, Elizabeth L; Queen, Suzanne E et al. (2017) Marked Enteropathy in an Accelerated Macaque Model of AIDS. Am J Pathol 187:589-604
Gannon, Patrick J; Akay-Espinoza, Cagla; Yee, Alan C et al. (2017) HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ?-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol 187:91-109
Yokley, Brian H; Hartman, Matthew; Slusher, Barbara S (2017) Role of Academic Drug Discovery in the Quest for New CNS Therapeutics. ACS Chem Neurosci 8:429-431
Rojas, Camilo; Stathis, Marigo; Coughlin, Jennifer M et al. (2017) The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site. J Neuroimmune Pharmacol :

Showing the most recent 10 out of 154 publications