The objectives of the Developmental Core are to: 1) promote innovative hypothesis driven, high-risk, high impact neuroaids research with aims relevant to the mission of NIMH;2) promote new kinds of cross disciplinary collaborations;3) to encourage the participation of new and established investigators and 4) to generate data and publications for use in applying for NIH and other peer funding. The Developmental Core has been largely successful in accomplishing these aims: Out of 18 pilot grants funded, 83% went to new investigators, 5/13 awardees have received subsequent NIH or other grants based on their pilot data, nine abstracts and five publications were published with 22 citations thus far. In this report we provide specific detail regarding the progress achieved by this Core. Several of the funded pilot projects have been collaborations between investigators with expertise in distinct areas of neuroscience and in a few cases, interdisciplinary in nature. In one collaboration, pilot data generated helped to further the aims of the Therapuetic Core and led to preliminary data for other program project grants (Shin/Steiner). The pilot program supported studies in a variety of areas in the neuroAIDS field including molecular, and cellular neuroscience, clinical, neuroimaging and animal studies thereby taking advantage of the expertise of the faculty at Johns Hopkins. One pilot project is focused on examining the relationship between aging and HIV associated neurocognitive disorder using neuroimaging (Mohamed), while another aims to understand the activation of brain endothelium in HAND (Sfins), both timely and emerging areas of investigation in neuroaids. Through the suggestions and assistance of members of the JHU NIMH Center, pilot awardees used the valuable resources of the MACS, and SHCS cohorts (Viscidi). The pilot grants allowed the pursuit of novel directions with a focus on the most at-risk populations under guided academic mentoring that might not otherwise have been accomplished due to lack of funds (Gamaldo). We expect that the full impact of the Development Core on the research capacity of JHU will be realized as more recently funded projects come to fruition and mature projects continue to grow.

Public Health Relevance

HIV/AIDS and its associated neurological complications remain a significant health care problem in the United States. The Developmental Core plays an essential role in supporting and facilitating the advancement of innovative, inter-disciplinary basic and clinical research in the area of HIV-associated neurocognitive disorders. Pilot research supported by the Developmental Core is expected to close gaps in our understanding of neurosis nathnaenesis and lead ultimately to new approaches to treat this disease.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Special Emphasis Panel (ZMH1-ERB-F)
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Johns Hopkins University
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Saylor, Deanna; Dickens, Alex M; Sacktor, Ned et al. (2016) HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol 12:234-48
Sacktor, Ned; Skolasky, Richard L; Seaberg, Eric et al. (2016) Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study. Neurology 86:334-40
Anderson, Brian A; Kronemer, Sharif I; Rilee, Jessica J et al. (2016) Reward, attention, and HIV-related risk in HIV+ individuals. Neurobiol Dis 92:157-65
Fazeli, Pariya L; Moore, David J; Franklin, Donald R et al. (2016) Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia. Curr HIV Res 14:324-30
Ramos, Félix M; Delgado-Vélez, Manuel; Ortiz, Ángel L et al. (2016) Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder. J Neurovirol 22:327-35
Kumar, Vivek; Bonifazi, Alessandro; Ellenberger, Michael P et al. (2016) Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J Med Chem 59:7634-50
Buchanan, Erin L; Espinoza, Diego A; McAlexander, Melissa A et al. (2016) SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load. Sci Rep 6:22629
Elgogary, Amira; Xu, Qingguo; Poore, Brad et al. (2016) Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A 113:E5328-36
Clifford, David B; Vaida, Florin; Kao, Yu-Ting et al. (2015) Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people. Neurology 84:241-50
Witwer, Kenneth W; Buchanan, Erin L; Myers, Stephanie L et al. (2015) miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease. J Neuroinflammation 12:159

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