Goals and objectives: The overarching theme of the Center is the development of novel therapeutics targeting sustained CNS inflammation for HIV-associated neurocognitive disorders (HAND). We have identified this as a high priority on the basis of our institutional strengths, our studies of neuropathogenesis, and the continuing importance in clinical care of these disorders. Organization of the Administrative Core The Administrative Core consists ofthe Executive Committee, an Operations Office, and an External Advisory Committee (EAC) to provide 'high-altitude'guidance and oversight. The Executive Committee consists ofthe Director, Co-Directors, and an administrator for the Center. Policies and procedures to be used by the Center are included in the Research Plan, and as Appendix material. Objectives of the Administrative Core To facilitate the development of novel therapeutics for HIV-associated neurocognitive disorders by facilitating collaborative research in HIV-related neuroscience among the widest possible range ofthe JHU academic community;increasing resources for HIV-related neuroscience;enhancing the productivity of HIV-related neuroscience research locally, nationally and internationally;encouraging high-risk, innovative 'developmental'research;encouraging and provide resources for new investigators;and providing educational resources for non-neurologists involved in HIV care for HIV-related neurological complications, and to facilitate participation in research. The core will also be responsible for the development of a web based, interactive "virtual cohort" to assemble individuals in the USA with HAND.

Public Health Relevance

HIV/AIDS is a major threat to global health and urban America, and HIV-associated-neurocognitive dysfunction remains prevalent even in HAART-treated people. Our research suggests that one ofthe drivers for this is sustained inflammation within the brain. Our Center has helped to coordinate and catalyze scientific and clinical resources at JHU to generate novel approaches to therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH075673-08
Application #
8525438
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$190,899
Indirect Cost
$45,499
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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