The objectives of the Developmental Core are to: 1) promote innovative hypothesis driven, high-risk, high impact neuroaids research with aims relevant to the mission of NIMH;2) promote new kinds of cross disciplinary collaborations;3) to encourage the participation of new and established investigators and 4) to generate data and publications for use in applying for NIH and other peer funding. The Developmental Core has been largely successful in accomplishing these aims: Out of 18 pilot grants funded, 83% went to new investigators, 5/13 awardees have received subsequent NIH or other grants based on their pilot data, nine abstracts and five publications were published with 22 citations thus far. In this report we provide specific detail regarding the progress achieved by this Core. Several of the funded pilot projects have been collaborations between investigators with expertise in distinct areas of neuroscience and in a few cases, interdisciplinary in nature. In one collaboration, pilot data generated helped to further the aims of the Therapuetic Core and led to preliminary data for other program project grants (Shin/Steiner). The pilot program supported studies in a variety of areas in the neuroAIDS field including molecular, and cellular neuroscience, clinical, neuroimaging and animal studies thereby taking advantage of the expertise of the faculty at Johns Hopkins. One pilot project is focused on examining the relationship between aging and HIV associated neurocognitive disorder using neuroimaging (Mohamed), while another aims to understand the activation of brain endothelium in HAND (Sfins), both timely and emerging areas of investigation in neuroaids. Through the suggestions and assistance of members of the JHU NIMH Center, pilot awardees used the valuable resources of the MACS, and SHCS cohorts (Viscidi). The pilot grants allowed the pursuit of novel directions with a focus on the most at-risk populations under guided academic mentoring that might not otherwise have been accomplished due to lack of funds (Gamaldo). We expect that the full impact of the Development Core on the research capacity of JHU will be realized as more recently funded projects come to fruition and mature projects continue to grow.
HIV/AIDS and its associated neurological complications remain a significant health care problem in the United States. The Developmental Core plays an essential role in supporting and facilitating the advancement of innovative, inter-disciplinary basic and clinical research in the area of HIV-associated neurocognitive disorders. Pilot research supported by the Developmental Core is expected to close gaps in our understanding of neurosis nathnaenesis and lead ultimately to new approaches to treat this disease.
|Sacktor, Ned; Nakasujja, Noeline; Redd, Andrew D et al. (2014) HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda. Metab Brain Dis 29:261-8|
|Meulendyke, Kelly A; Croteau, Joshua D; Zink, M Christine (2014) HIV life cycle, innate immunity and autophagy in the central nervous system. Curr Opin HIV AIDS 9:565-71|
|Sacktor, Ned; Miyahara, Sachiko; Evans, Scott et al. (2014) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol 20:620-6|
|Gamaldo, Charlene E; Gamaldo, Alyssa; McArthur, Justin C et al. (2014) Reply: To PMID 23722610. J Acquir Immune Defic Syndr 65:e124-5|
|Hulgan, Todd; Levinson, Rebecca T; Gerschenson, Mariana et al. (2014) Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy. AIDS 28:1625-33|
|Yu, Ian W; Espinoza, Diego A; McAlexander, Melissa A et al. (2014) OpenArray profiling reveals no differential modulation of miRNA by positive and negative CD4+ T cell immunoselection. Exp Hematol 42:11-3|
|Figuera-Losada, Mariana; Rojas, Camilo; Slusher, Barbara S (2014) Inhibition of microglia activation as a phenotypic assay in early drug discovery. J Biomol Screen 19:17-31|
|Bora, Adriana; Ubaida Mohien, Ceereena; Chaerkady, Raghothama et al. (2014) Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass spectrometry. J Neurovirol 20:457-65|
|Bae, Mihyun; Patel, Neha; Xu, Haoxing et al. (2014) Activation of TRPML1 clears intraneuronal A? in preclinical models of HIV infection. J Neurosci 34:11485-503|
|Meulendyke, Kelly A; Queen, Suzanne E; Engle, Elizabeth L et al. (2014) Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease. J Neurovirol 20:591-602|
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