The proposed renewal of the Johns Hopkins University (JHU) Center will continue to be led by Director Dr. Jusfin C McArthur. To manage the Center, centralize administrative functions, and most efficiently support the Center-affiliated faculty at JHU, we propose to have the same leadership for the Administrative Core (AC) as for the overall Center's Executive Committee. The AC will be supported by the Center's Administrative Assistant. The AC will serve as the administrative base of the Center and will continue to be housed within the University's Department of Neurology, located on the Johns Hopkins Medical Institutions (JHMI) campus which will enable efficient management across the three affiliated Schools of Medicine (SOM), Bloomberg School of Public Health (BSPH), and School of Nursing (SON). The rafionale for a centralized AC is to have stream lined management and administration in order to maximize efficiency of personnel, resources and ease of use for CFAR researchers, provide overall scientific and programmafic leadership, fiscal oversight and support, and to integrate communicafions and informafion resources to maximize CFAR utility, value, and cohesiveness in support of HIV research at Johns Hopkins. Administrative and financial management, as well as compliance oversight, will be managed through the Office of the Vice Dean for Research in the School of Medicine. The overarching theme of the Center is the development of novel therapeutics targeting sustained CNS inflammation for HIV-associated neurocognitive disorders (HAND). We have identified this as a high priority on the basis of our institutional strengths, our studies of neuropathogenesis both in humans and SIV encephalitis models, and the confinuing importance in clinical care of these disorders.
HIV/AIDS is a major threat to global health and urban America, and HIV-associated-neurocognitive dysfunction remains prevalent even in HAART-treated people. Our research suggests that one ofthe drivers for this is sustained inflammation within the brain. Our Center has helped to coordinate and catalyze scientific and clinical resources at JHU to generate novel approaches to therapy.
|Saylor, Deanna; Dickens, Alex M; Sacktor, Ned et al. (2016) HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol 12:234-48|
|Sacktor, Ned; Skolasky, Richard L; Seaberg, Eric et al. (2016) Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study. Neurology 86:334-40|
|Anderson, Brian A; Kronemer, Sharif I; Rilee, Jessica J et al. (2016) Reward, attention, and HIV-related risk in HIV+ individuals. Neurobiol Dis 92:157-65|
|Fazeli, Pariya L; Moore, David J; Franklin, Donald R et al. (2016) Lower CSF AÎ² is Associated with HAND in HIV-Infected Adults with a Family History of Dementia. Curr HIV Res 14:324-30|
|Ramos, FÃ©lix M; Delgado-VÃ©lez, Manuel; Ortiz, Ãngel L et al. (2016) Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder. J Neurovirol 22:327-35|
|Kumar, Vivek; Bonifazi, Alessandro; Ellenberger, Michael P et al. (2016) Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J Med Chem 59:7634-50|
|Buchanan, Erin L; Espinoza, Diego A; McAlexander, Melissa A et al. (2016) SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load. Sci Rep 6:22629|
|Elgogary, Amira; Xu, Qingguo; Poore, Brad et al. (2016) Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A 113:E5328-36|
|Clifford, David B; Vaida, Florin; Kao, Yu-Ting et al. (2015) Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people. Neurology 84:241-50|
|Witwer, Kenneth W; Buchanan, Erin L; Myers, Stephanie L et al. (2015) miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease. J Neuroinflammation 12:159|
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