The objectives of the Developmental Core are to: 1) promote innovative hypothesis driven, high-risk, high impact neuroaids research with aims relevant to the mission of NIMH;2) promote new kinds of cross disciplinary collaborations;3) to encourage the participation of new and established investigators and 4) to generate data and publications for use in applying for NIH and other peer funding. The Developmental Core has been largely successful in accomplishing these aims: Out of 18 pilot grants funded, 83% went to new investigators, 5/13 awardees have received subsequent NIH or other grants based on their pilot data, nine abstracts and five publications were published with 22 citations thus far. In this report we provide specific detail regarding the progress achieved by this Core. Several of the funded pilot projects have been collaborations between investigators with expertise in distinct areas of neuroscience and in a few cases, interdisciplinary in nature. In one collaboration, pilot data generated helped to further the aims of the Therapuetic Core and led to preliminary data for other program project grants (Shin/Steiner). The pilot program supported studies in a variety of areas in the neuroAIDS field including molecular, and cellular neuroscience, clinical, neuroimaging and animal studies thereby taking advantage of the expertise of the faculty at Johns Hopkins. One pilot project is focused on examining the relationship between aging and HIV associated neurocognitive disorder using neuroimaging (Mohamed), while another aims to understand the activation of brain endothelium in HAND (Sfins), both timely and emerging areas of investigation in neuroaids. Through the suggestions and assistance of members of the JHU NIMH Center, pilot awardees used the valuable resources of the MACS, and SHCS cohorts (Viscidi). The pilot grants allowed the pursuit of novel directions with a focus on the most at-risk populations under guided academic mentoring that might not otherwise have been accomplished due to lack of funds (Gamaldo). We expect that the full impact of the Development Core on the research capacity of JHU will be realized as more recently funded projects come to fruition and mature projects continue to grow.

Public Health Relevance

HIV/AIDS and its associated neurological complications remain a significant health care problem in the United States. The Developmental Core plays an essential role in supporting and facilitating the advancement of innovative, inter-disciplinary basic and clinical research in the area of HIV-associated neurocognitive disorders. Pilot research supported by the Developmental Core is expected to close gaps in our understanding of neurosis nathnaenesis and lead ultimately to new approaches to treat this disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH075673-09
Application #
8690145
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
9
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Mohamed, M; Barker, P B; Skolasky, R L et al. (2018) 7T Brain MRS in HIV Infection: Correlation with Cognitive Impairment and Performance on Neuropsychological Tests. AJNR Am J Neuroradiol 39:704-712
Sacktor, Ned; Skolasky, Richard L; Moxley, Richard et al. (2018) Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial. J Neurovirol 24:16-27
Barinka, Cyril; Novakova, Zora; Hin, Niyada et al. (2018) Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors. Bioorg Med Chem :
Lemberg, Kathryn M; Vornov, James J; Rais, Rana et al. (2018) We're Not ""DON"" Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine. Mol Cancer Ther 17:1824-1832
Capó-Vélez, Coral M; Delgado-Vélez, Manuel; Báez-Pagán, Carlos A et al. (2018) Nicotinic Acetylcholine Receptors in HIV: Possible Roles During HAND and Inflammation. Cell Mol Neurobiol :
Nedelcovych, Michael T; Gadiano, Alexandra J; Wu, Ying et al. (2018) Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse. ACS Chem Neurosci 9:809-816
Sacktor, Ned (2018) Changing clinical phenotypes of HIV-associated neurocognitive disorders. J Neurovirol 24:141-145
Capó-Vélez, Coral M; Morales-Vargas, Bryan; García-González, Aurian et al. (2018) The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders. Sci Rep 8:1829
Rubin, Leah H; Sacktor, Ned; Creighton, Jason et al. (2018) Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy. AIDS 32:1661-1667
Chaudhuri, Amrita Datta; Dastgheyb, Raha M; Yoo, Seung-Wan et al. (2018) TNF? and IL-1? modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons. Cell Death Dis 9:363

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