We propose a novel program of personalized interventions stimulated by our work with depressed elders at risk for adverse outcomes and with settings rarely targeted by research. Our interventions will be developed jointly with indigenous community services and consist of clinically-informed treatment algorithms, targeted training of community workers, and organizational changes of community services. To meet these challenges, the OG must serve as the ACISR's hub and: 1. Utilize our organizational experience in integrating research activities into a cohesive, seamlessly-working system that fosters innovation, maximizes the ACISR's research capacity and ensures research excellence;2. extend our research structures for ethics, scientific and logistic support, and training of staff;3. rely on our "know-how", history and explicit plans in developing sustained partnerships with community agencies and learning from them;4. capitalize on our methodological rigor in data management, and analysis;and 5. bring to bear our experience and commitment to career development. These tasks are integrated in 5 Units: Administrative Unit (AU): The AU synthesizes the ACISR's research, methodology, community, and training activities and ethical concerns into a cohesive scientific program and develops the operational platform to foster innovation, ensure research excellence and efficiency, and promote dissemination. Interventions Management Unit (IMU): The IMU provides scientific and logistic support to funded and pilot studies on predictors of outcomes, intervention development, ethics review, design, training of staff, and protocol implementation by the ACISR and its community partners. Community Network Unit (CNU): The CNU cultivates and sustains partnerships with community agencies with the goal to conduct collaborative research aiming to improve the quality of care of often neglected, depressed elders, at risk for adverse outcomes. Biostatistics and Data Management Unit (BDM): The BDM provides expertise, quality control, and training in design, data management and data analysis. Training and Career Development Unit (TCU): The TCU fosters research training and career development in geriatric mood disorders at Cornell and offer leadership in career development at a national level.

Public Health Relevance

The OC will support a challenging program that extends our studies of moderators and predictors of treatment outcomes, uses their findings as a stimulus for developing personalized interventions for hard to access and difficult to treat depressed seniors and shortens the road from discovery to real world practice.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Special Emphasis Panel (ZMH1-ERB-B)
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Weill Medical College of Cornell University
New York
United States
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Alexopoulos, George S; Raue, Patrick J; Kiosses, Dimitris N et al. (2015) Comparing engage with PST in late-life major depression: a preliminary report. Am J Geriatr Psychiatry 23:506-13
Yuen, Genevieve S; Bhutani, Saumya; Lucas, Bryony J et al. (2015) Apathy in late-life depression: common, persistent, and disabling. Am J Geriatr Psychiatry 23:488-94
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Yuen, Genevieve S; Gunning-Dixon, Faith M; Hoptman, Matthew J et al. (2014) The salience network in the apathy of late-life depression. Int J Geriatr Psychiatry 29:1116-24
Raue, Patrick J; Ghesquiere, Angela R; Bruce, Martha L (2014) Suicide risk in primary care: identification and management in older adults. Curr Psychiatry Rep 16:466
Alexopoulos, George S; Kiosses, Dimitris N; Sirey, Jo Anne et al. (2014) Untangling therapeutic ingredients of a personalized intervention for patients with depression and severe COPD. Am J Geriatr Psychiatry 22:1316-24
Yuen, Genevieve S; Gunning, Faith M; Woods, Eric et al. (2014) Neuroanatomical correlates of apathy in late-life depression and antidepressant treatment response. J Affect Disord 166:179-86

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