We propose a novel program of personalized interventions stimulated by our work with depressed elders at risk for adverse outcomes and with settings rarely targeted by research. Our interventions will be developed jointly with indigenous community services and consist of clinically-informed treatment algorithms, targeted training of community workers, and organizational changes of community services. To meet these challenges, the OG must serve as the ACISR's hub and: 1. Utilize our organizational experience in integrating research activities into a cohesive, seamlessly-working system that fosters innovation, maximizes the ACISR's research capacity and ensures research excellence;2. extend our research structures for ethics, scientific and logistic support, and training of staff;3. rely on our """"""""know-how"""""""", history and explicit plans in developing sustained partnerships with community agencies and learning from them;4. capitalize on our methodological rigor in data management, and analysis;and 5. bring to bear our experience and commitment to career development. These tasks are integrated in 5 Units: Administrative Unit (AU): The AU synthesizes the ACISR's research, methodology, community, and training activities and ethical concerns into a cohesive scientific program and develops the operational platform to foster innovation, ensure research excellence and efficiency, and promote dissemination. Interventions Management Unit (IMU): The IMU provides scientific and logistic support to funded and pilot studies on predictors of outcomes, intervention development, ethics review, design, training of staff, and protocol implementation by the ACISR and its community partners. Community Network Unit (CNU): The CNU cultivates and sustains partnerships with community agencies with the goal to conduct collaborative research aiming to improve the quality of care of often neglected, depressed elders, at risk for adverse outcomes. Biostatistics and Data Management Unit (BDM): The BDM provides expertise, quality control, and training in design, data management and data analysis. Training and Career Development Unit (TCU): The TCU fosters research training and career development in geriatric mood disorders at Cornell and offer leadership in career development at a national level.

Public Health Relevance

The OC will support a challenging program that extends our studies of moderators and predictors of treatment outcomes, uses their findings as a stimulus for developing personalized interventions for hard to access and difficult to treat depressed seniors and shortens the road from discovery to real world practice.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-B)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Weill Medical College of Cornell University
New York
United States
Zip Code
Alexopoulos, George S; Raue, Patrick J; Gunning, Faith et al. (2016) ""Engage"" Therapy: Behavioral Activation and Improvement of Late-Life Major Depression. Am J Geriatr Psychiatry 24:320-6
Gustavson, Kristen A; Alexopoulos, George S; Niu, Grace C et al. (2016) Problem-Solving Therapy Reduces Suicidal Ideation In Depressed Older Adults with Executive Dysfunction. Am J Geriatr Psychiatry 24:11-7
Bogner, Hillary R; Joo, Jin H; Hwang, Seungyoung et al. (2016) Does a Depression Management Program Decrease Mortality in Older Adults with Specific Medical Conditions in Primary Care? An Exploratory Analysis. J Am Geriatr Soc 64:126-31
Yohannes, Abebaw Mengistu; Raue, Patrick J; Kanellopoulos, Dora et al. (2016) Predictors of All-Cause Mortality in Patients With Severe COPD and Major Depression Admitted to a Rehabilitation Hospital. Chest 149:467-73
Mahgoub, Nahla; Alexopoulos, George S (2016) Amyloid Hypothesis: Is There a Role for Antiamyloid Treatment in Late-Life Depression? Am J Geriatr Psychiatry 24:239-47
Alexopoulos, George S; Sirey, Jo Anne; Banerjee, Samprit et al. (2016) Two Behavioral Interventions for Patients with Major Depression and Severe COPD. Am J Geriatr Psychiatry 24:964-974
Gallo, Joseph J; Hwang, Seungyoung; Joo, Jin Hui et al. (2016) Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk. J Gen Intern Med 31:380-6
Alexopoulos, George S; Raue, Patrick J; McCulloch, Charles et al. (2016) Clinical Case Management versus Case Management with Problem-Solving Therapy in Low-Income, Disabled Elders with Major Depression: A Randomized Clinical Trial. Am J Geriatr Psychiatry 24:50-9
Alexopoulos, George S; Raue, Patrick J; Kiosses, Dimitris N et al. (2015) Comparing engage with PST in late-life major depression: a preliminary report. Am J Geriatr Psychiatry 23:506-13
Kiosses, Dimitris N; Ravdin, Lisa D; Gross, James J et al. (2015) Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial. JAMA Psychiatry 72:22-30

Showing the most recent 10 out of 68 publications