Abstract

Depressive symptoms are common in seniors receiving in-home and community-based services. In seniors receiving home-delivered meals, 12% reported clinically significant depression (PHQ >9).(177) In seniors receiving home health nursing, 13.5% met criteria for major depression.(178) The 1 -year incidence of major depression in homebound elders was 3%, and the 1-year incidence for minor depression 7%. (179) Thus, the population of seniors receiving aging services is at high risk for depression and an appropriate target for selective and indicated prevention. Prevention is likely to be highly effective in these seniors, who share many of the depression risk factors identified in epidemiologic research (functional impairments, two or more chronic illnesses, low educational level, and living without a partner, which in one Dutch study identified the 8-10% of the senior population at highest risk for depression).(180-181) Interventions targeting this population could reduce the incidence of depression by one-third to one-half, generating large health gains efficiently, with numbers-needed-to-treat as low as 3-5. (182)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH090333-02
Application #
8377364
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
2
Fiscal Year
2012
Total Cost
$126,310
Indirect Cost
$42,937

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Wei, Wenjing; Karim, Helmet T; Lin, Chemin et al. (2018) Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis. J Clin Psychiatry 79:
Karim, Helmet T; Wang, Maxwell; Andreescu, Carmen et al. (2018) Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin 19:831-839
Rodakowski, Juleen; Reynolds 3rd, Charles F; Lopez, Oscar L et al. (2018) Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment. J Appl Gerontol 37:665-676
Miller, Rachel G; Anderson, Stewart J; Costacou, Tina et al. (2018) Hemoglobin A1c Level and Cardiovascular Disease Incidence in Persons With Type 1 Diabetes: An Application of Joint Modeling of Longitudinal and Time-to-Event Data in the Pittsburgh Epidemiology of Diabetes Complications Study. Am J Epidemiol 187:1520-1529
Gebara, Marie Anne; DiNapoli, Elizabeth A; Kasckow, John et al. (2018) Specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression. Int J Geriatr Psychiatry 33:e330-e335
Okereke, Olivia I; Reynolds 3rd, Charles F; Mischoulon, David et al. (2018) The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression. Contemp Clin Trials 68:133-145
Gebara, Marie Anne; Kasckow, John; Smagula, Stephen F et al. (2018) The role of late life depressive symptoms on the trajectories of insomnia symptoms during antidepressant treatment. J Psychiatr Res 96:162-166
Cohen, Alex; Dias, Amit; Azariah, Fredric et al. (2018) Aging and well-being in Goa, India: a qualitative study. Aging Ment Health 22:168-174
Chen, Jie; Bloodworth, Robin; Novak, Priscilla et al. (2018) Reducing Preventable Hospitalization and Disparity: Association With Local Health Department Mental Health Promotion Activities. Am J Prev Med 54:103-112
Oberlin, Lauren E; Waiwood, Aashna M; Cumming, Toby B et al. (2017) Effects of Physical Activity on Poststroke Cognitive Function: A Meta-Analysis of Randomized Controlled Trials. Stroke 48:3093-3100

Showing the most recent 10 out of 175 publications