The Operations Core provides services to the Principal Research Core and the Research Methods Core. The Administrative Unit provides an organizational and financial structure, scientific oversight (via external and internal scientific advisory committees as well as a seed money peer review committee), and research training oversight (including research ethics). The Prevention Trials Unit recruits sites and subjects and carries out assessment and intervention training, implementation, and adherence. The Community Network Unit promotes community-partnered research subject and site recruitment across the Center through its Community Advisory Board and inclusion of partner interests and agendas in Principal Research Core efforts The Biosignatures Service and Integration Unit provides consultation and collaboration on a range of biomarkers (genetics, cytokines, medication levels, sleep, and neuroimaging) in the service of developing personalized preventive interventions practicable in community-based settings. Finally, the Data Management and Analysis Unit provides specific data management services, collaborates with other units in the Operations Core (Prevention, Biosignatures, Community Network) to ensure standardization of all measures used, and participates in the analysis of protocol data and in the preparation of related manuscripts.

Public Health Relevance

The Operations Core provides organizational support/infrastructure and financial oversight of all Center activities, to ensure mission-relevance to research in late-life depression prevention. The Core also administers a seed money program and team-based research mentoring to support research career development of Early Stage Investigators in depression prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH090333-03
Application #
8465283
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
3
Fiscal Year
2013
Total Cost
$715,016
Indirect Cost
$344,553
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Wei, Wenjing; Karim, Helmet T; Lin, Chemin et al. (2018) Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis. J Clin Psychiatry 79:
Karim, Helmet T; Wang, Maxwell; Andreescu, Carmen et al. (2018) Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. Neuroimage Clin 19:831-839
Rodakowski, Juleen; Reynolds 3rd, Charles F; Lopez, Oscar L et al. (2018) Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment. J Appl Gerontol 37:665-676
Miller, Rachel G; Anderson, Stewart J; Costacou, Tina et al. (2018) Hemoglobin A1c Level and Cardiovascular Disease Incidence in Persons With Type 1 Diabetes: An Application of Joint Modeling of Longitudinal and Time-to-Event Data in the Pittsburgh Epidemiology of Diabetes Complications Study. Am J Epidemiol 187:1520-1529
Gebara, Marie Anne; DiNapoli, Elizabeth A; Kasckow, John et al. (2018) Specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression. Int J Geriatr Psychiatry 33:e330-e335
Okereke, Olivia I; Reynolds 3rd, Charles F; Mischoulon, David et al. (2018) The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression. Contemp Clin Trials 68:133-145
Gebara, Marie Anne; Kasckow, John; Smagula, Stephen F et al. (2018) The role of late life depressive symptoms on the trajectories of insomnia symptoms during antidepressant treatment. J Psychiatr Res 96:162-166
Cohen, Alex; Dias, Amit; Azariah, Fredric et al. (2018) Aging and well-being in Goa, India: a qualitative study. Aging Ment Health 22:168-174
Chen, Jie; Bloodworth, Robin; Novak, Priscilla et al. (2018) Reducing Preventable Hospitalization and Disparity: Association With Local Health Department Mental Health Promotion Activities. Am J Prev Med 54:103-112
Diniz, Breno Satler; Reynolds 3rd, Charles F; Sibille, Etienne et al. (2017) Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype. Am J Geriatr Psychiatry 25:64-72

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