The Operations Core provides services to the Principal Research Core and the Research Methods Core. The Administrative Unit provides an organizational and financial structure, scientific oversight (via external and internal scientific advisory committees as well as a seed money peer review committee), and research training oversight (including research ethics). The Prevention Trials Unit recruits sites and subjects and carries out assessment and intervention training, implementation, and adherence. The Community Network Unit promotes community-partnered research subject and site recruitment across the Center through its Community Advisory Board and inclusion of partner interests and agendas in Principal Research Core efforts The Biosignatures Service and Integration Unit provides consultation and collaboration on a range of biomarkers (genetics, cytokines, medication levels, sleep, and neuroimaging) in the service of developing personalized preventive interventions practicable in community-based settings. Finally, the Data Management and Analysis Unit provides specific data management services, collaborates with other units in the Operations Core (Prevention, Biosignatures, Community Network) to ensure standardization of all measures used, and participates in the analysis of protocol data and in the preparation of related manuscripts.

Public Health Relevance

The Operations Core provides organizational support/infrastructure and financial oversight of all Center activities, to ensure mission-relevance to research in late-life depression prevention. The Core also administers a seed money program and team-based research mentoring to support research career development of Early Stage Investigators in depression prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH090333-04
Application #
8659201
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
$831,796
Indirect Cost
$282,757
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kaneriya, Shriya H; Robbins-Welty, Gregg A; Smagula, Stephen F et al. (2016) Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial. JAMA Psychiatry 73:329-36
Gildengers, Ariel G; Butters, Meryl A; Albert, Steven M et al. (2016) Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL). Am J Geriatr Psychiatry 24:444-54
Baglioni, Chiara; Nanovska, Svetoslava; Regen, Wolfram et al. (2016) Sleep and mental disorders: A meta-analysis of polysomnographic research. Psychol Bull 142:969-990
Vanyukov, Polina M; Szanto, Katalin; Hallquist, Michael et al. (2016) Perceived burdensomeness is associated with low-lethality suicide attempts, dysfunctional interpersonal style, and younger rather than older age. Int J Geriatr Psychiatry :
Gallo, Joseph J; Hwang, Seungyoung; Joo, Jin Hui et al. (2016) Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk. J Gen Intern Med 31:380-6
Ogbagaber, Semhar B; Karp, Jordan; Wahed, Abdus S (2016) Design of sequentially randomized trials for testing adaptive treatment strategies. Stat Med 35:840-58
Karp, Jordan F; Dew, Mary Amanda; Wahed, Abdus S et al. (2016) Challenges and Solutions for Depression Prevention Research: Methodology for a Depression Prevention Trial for Older Adults with Knee Arthritis and Emotional Distress. Am J Geriatr Psychiatry 24:433-43
Hsu, Jonathan H; Mulsant, Benoit H; Lenze, Eric J et al. (2016) Impact of Prior Treatment on Remission of Late-Life Depression with Venlafaxine and Subsequent Aripiprazole or Placebo Augmentation. Am J Geriatr Psychiatry 24:918-22
Smagula, Stephen F; Wallace, Meredith L; Anderson, Stewart J et al. (2016) Combining moderators to identify clinical profiles of patients who will, and will not, benefit from aripiprazole augmentation for treatment resistant late-life major depressive disorder. J Psychiatr Res 81:112-8
Rodakowski, Juleen; Reynolds 3rd, Charles F; Lopez, Oscar L et al. (2016) Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment. J Appl Gerontol :

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