The Overview to our Center application elucidates our vision of how and why late life depression prevention effectiveness research must be advanced in the next five years. The Research Methods Core (RMC) will provide the infrastructure to support the development of innovative methodologies to address the research issues and goals that emerge from this vision. Thus, the RMC will forge methodologic bridges between the Center's overall vision, on the one hand, and the research to be accomplished in order to meet it. An equally important RMC goal is to contribute to progress of the science of prevention research?at both the level of effectiveness assessment and the level of sustainability and transfer?within the mental health and aging research and practice communities. The RMC will accomplish these objectives through the efforts of a unified, multidisciplinary team of methodologists. This team will be organized into three subgroups (Units) with expertise brought to bear on specific methodologic areas: 1. The Assessment of Risk and Intervention Outcomes Unit will focus on the development and application of a new generation of electronic assessment strategies for measuring both risk factors and intervention outcomes in depression prevention trials. Domains of focus include the measurement of depressive symptoms and symptoms of other comorbidities;cognitive status;and overall functional status and disability. 2. The Research Design and Biostatistics Unit will focus on the development and application of models to characterize dynamic patterns of risk factors and transition between states/levels of depression, as well as on the development of methods to promote the efficient analysis of data from response-adaptive allocation research designs. 3. The Implementation. Portabilitv. Sustainabilitv and Migration Unit will focus on the application of tools to promote intervention dissemination and sustainability, with an emphasis on the use of methods that better characterize the content and delivery of interventions, as well as determine interventions'economic feasibility. Moreover, this Unit will work on the development and initial testing of strategies to migrate traditional interventions to electronic delivery modes. Within each RMC Unit, work will be pursued at two levels of function: (a) direct research investigation of new tools and approaches, utilizing the Principal Research Core projects as critical platforms for this work and (b) dissemination and training efforts both within and beyond the Center, involving close liaisons with the Operations Core so that new RMC tools and approaches can be smoothly transferred to the Operations Core 'loolbox"""""""" of Center resources and strategies.

Public Health Relevance

The Research Methods Core (RMC) will support the development of methodological advances essential for the science of depression prevention, including new methods for assessment, statistical modeling of risk and outcomes of interventions, and dissemination of effective interventions. Work to be pursued will employ Principal Research Core projects as critical platforms for testing new methodologic tools, and results of this work will then be transferred to the Operations Core to be added to the toolbox of Center resources and strategies available for depression prevention researchers.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Special Emphasis Panel (ZMH1-ERB-F)
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University of Pittsburgh
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Kaneriya, Shriya H; Robbins-Welty, Gregg A; Smagula, Stephen F et al. (2016) Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial. JAMA Psychiatry 73:329-36
Gildengers, Ariel G; Butters, Meryl A; Albert, Steven M et al. (2016) Design and Implementation of an Intervention Development Study: Retaining Cognition While Avoiding Late-Life Depression (ReCALL). Am J Geriatr Psychiatry 24:444-54
Baglioni, Chiara; Nanovska, Svetoslava; Regen, Wolfram et al. (2016) Sleep and mental disorders: A meta-analysis of polysomnographic research. Psychol Bull 142:969-990
Vanyukov, Polina M; Szanto, Katalin; Hallquist, Michael et al. (2016) Perceived burdensomeness is associated with low-lethality suicide attempts, dysfunctional interpersonal style, and younger rather than older age. Int J Geriatr Psychiatry :
Gallo, Joseph J; Hwang, Seungyoung; Joo, Jin Hui et al. (2016) Multimorbidity, Depression, and Mortality in Primary Care: Randomized Clinical Trial of an Evidence-Based Depression Care Management Program on Mortality Risk. J Gen Intern Med 31:380-6
Ogbagaber, Semhar B; Karp, Jordan; Wahed, Abdus S (2016) Design of sequentially randomized trials for testing adaptive treatment strategies. Stat Med 35:840-58
Karp, Jordan F; Dew, Mary Amanda; Wahed, Abdus S et al. (2016) Challenges and Solutions for Depression Prevention Research: Methodology for a Depression Prevention Trial for Older Adults with Knee Arthritis and Emotional Distress. Am J Geriatr Psychiatry 24:433-43
Hsu, Jonathan H; Mulsant, Benoit H; Lenze, Eric J et al. (2016) Impact of Prior Treatment on Remission of Late-Life Depression with Venlafaxine and Subsequent Aripiprazole or Placebo Augmentation. Am J Geriatr Psychiatry 24:918-22
Smagula, Stephen F; Wallace, Meredith L; Anderson, Stewart J et al. (2016) Combining moderators to identify clinical profiles of patients who will, and will not, benefit from aripiprazole augmentation for treatment resistant late-life major depressive disorder. J Psychiatr Res 81:112-8
Rodakowski, Juleen; Reynolds 3rd, Charles F; Lopez, Oscar L et al. (2016) Developing a Non-Pharmacological Intervention for Individuals With Mild Cognitive Impairment. J Appl Gerontol :

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