The main objective of this application is to establish a Comprehensive NeuroAIDS Core Center (CNACC) at Temple University with the goal to improve and expand research related to HIV-1/AIDS and its associated neurological and mental disorders. The infrastructure built through this core facility will provide local and regional investigators with broad, reliable and efficient services including establishing primary mammalian cell culture from brain and virus infection, gene expression and proteomics analysis at the tissue, cellular, and molecular levels to unravel the mechanisms of disease and discoveries of new biomarkers, developing new experimental animals to investigate the molecular biology, pathogenesis, and cognitive aspects of HIV-1 CNS disease, and clinical and neurobehavioral examination at both domestic and international levels. The Administrative Core will provide the infrastructure for coordinating and overseeing all activities of the CNACC including delineation of the strategic plan, identification of short and long term objectives, execution of detailed plans to be implemented, carrying out internal and external reviews and assessment tools based on established criteria to ensure productive and efficient use of resources to achieve the overall objectives of CNACC and offer biostatistical support for data analysis and interpretation obtained from basic science and clinical cores.

Public Health Relevance

This project will be responsible for administrative oversight of the comprehensive neuroAIDS core center to ensure productive and efficient use of the core resources in providing the highest level of service to the neuroAIDS community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH092177-03
Application #
8477299
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$327,852
Indirect Cost
$113,570
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
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Dampier, Will; Antell, Gregory C; Aiamkitsumrit, Benjamas et al. (2017) Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status. J Neurovirol 23:113-124
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