The main objective of this application is to establish a Comprehensive NeuroAIDS Core Center (CNACC) at Temple University with the goal to improve and expand research related to HIV-1/AIDS and its associated neurological and mental disorders. The infrastructure built through this core facility will provide local and regional investigators with broad, reliable and efficient services including establishing primary mammalian cell culture from brain and virus infection, gene expression and proteomics analysis at the tissue, cellular, and molecular levels to unravel the mechanisms of disease and discoveries of new biomarkers, developing new experimental animals to investigate the molecular biology, pathogenesis, and cognitive aspects of HIV-1 CNS disease, and clinical and neurobehavioral examination at both domestic and international levels. The Administrative Core will provide the infrastructure for coordinating and overseeing all activities of the CNACC including delineation of the strategic plan, identification of short and long term objectives, execution of detailed plans to be implemented, carrying out internal and external reviews and assessment tools based on established criteria to ensure productive and efficient use of resources to achieve the overall objectives of CNACC and offer biostatistical support for data analysis and interpretation obtained from basic science and clinical cores.

Public Health Relevance

This project will be responsible for administrative oversight of the comprehensive neuroAIDS core center to ensure productive and efficient use of the core resources in providing the highest level of service to the neuroAIDS community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH092177-03
Application #
8477299
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$327,852
Indirect Cost
$113,570
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Dampier, Will; Antell, Gregory C; Aiamkitsumrit, Benjamas et al. (2016) Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status. J Neurovirol :
Datta, Prasun K; Kaminski, Rafal; Hu, Wenhui et al. (2016) HIV-1 Latency and Eradication: Past, Present and Future. Curr HIV Res 14:431-441
Sariyer, Rahsan; De-Simone, Francesca Isabella; Gordon, Jennifer et al. (2016) Immune suppression of JC virus gene expression is mediated by SRSF1. J Neurovirol :
Kaminski, Rafal; Chen, Yilan; Fischer, Tracy et al. (2016) Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Sci Rep 6:22555
Regan, Patrick M; Sariyer, Ilker K; Langford, T Dianne et al. (2016) Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X Signaling. J Cell Physiol 231:1542-53
Zhong, Lin; Li, Hao; Li, Zhiqiang et al. (2016) C7 genotype of the donor may predict early bacterial infection after liver transplantation. Sci Rep 6:24121
Strazza, Marianne; Pirrone, Vanessa; Wigdahl, Brian et al. (2016) Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier. Int J Mol Sci 17:
Kaminski, R; Bella, R; Yin, C et al. (2016) Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study. Gene Ther 23:690-5
Wollebo, Hassen S; Bellizzi, Anna; Cossari, Dominique H et al. (2016) The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. J Neurovirol 22:615-625
Feng, Dechun; Dai, Shen; Liu, Fengming et al. (2016) Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clin Invest 126:2321-33

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