The main objective of this application is to establish a Comprehensive NeuroAIDS Core Center (CNACC) at Temple University with the goal to improve and expand research related to HIV-1/AIDS and its associated neurological and mental disorders. The infrastructure built through this core facility will provide local and regional investigators with broad, reliable and efficient services including establishing primary mammalian cell culture from brain and virus infection, gene expression and proteomics analysis at the tissue, cellular, and molecular levels to unravel the mechanisms of disease and discoveries of new biomarkers, developing new experimental animals to investigate the molecular biology, pathogenesis, and cognitive aspects of HIV-1 CNS disease, and clinical and neurobehavioral examination at both domestic and international levels. The Administrative Core will provide the infrastructure for coordinating and overseeing all activities of the CNACC including delineation of the strategic plan, identification of short and long term objectives, execution of detailed plans to be implemented, carrying out internal and external reviews and assessment tools based on established criteria to ensure productive and efficient use of resources to achieve the overall objectives of CNACC and offer biostatistical support for data analysis and interpretation obtained from basic science and clinical cores.

Public Health Relevance

This project will be responsible for administrative oversight of the comprehensive neuroAIDS core center to ensure productive and efficient use of the core resources in providing the highest level of service to the neuroAIDS community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH092177-04
Application #
8668158
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
4
Fiscal Year
2014
Total Cost
$341,468
Indirect Cost
$149,459
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Wang, Jin Ying; Darbinyan, Armine; White, Martyn K et al. (2014) Involvement of IRS-1 interaction with ADAM10 in the regulation of neurite extension. J Cell Physiol 229:1039-46
Dahiya, Satinder; Liu, Yujie; Nonnemacher, Michael R et al. (2014) CCAAT enhancer binding protein and nuclear factor of activated T cells regulate HIV-1 LTR via a novel conserved downstream site in cells of the monocyte-macrophage lineage. PLoS One 9:e88116
Palma, Jonathan; Abood, Mary E; Barbe, Mary F et al. (2014) Functional interaction between HIV-gp120 and opioid system in the preoptic anterior hypothalamus. Drug Alcohol Depend 134:383-6
White, Martyn K; Kaminski, Rafal; Khalili, Kamel et al. (2014) Rad51 activates polyomavirus JC early transcription. PLoS One 9:e110122
Pozniak, Paul D; White, Martyn K; Khalili, Kamel (2014) TNF-*/NF-*B signaling in the CNS: possible connection to EPHB2. J Neuroimmune Pharmacol 9:133-41
Gill, Alexander J; Kovacsics, Colleen E; Cross, Stephanie A et al. (2014) Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders. J Clin Invest 124:4459-72
Strazza, Marianne; Banerjee, Anupam; Alexaki, Aikaterini et al. (2014) Effect of ?-opioid agonist DAMGO on surface CXCR4 and HIV-1 replication in TF-1 human bone marrow progenitor cells. BMC Res Notes 7:752
Fischer, Tracy; Wyatt, Christina M; D'Agati, Vivette D et al. (2014) Mononuclear phagocyte accumulation in visceral tissue in HIV encephalitis: evidence for increased monocyte/macrophage trafficking and altered differentiation. Curr HIV Res 12:201-12
Aiamkitsumrit, Benjamas; Dampier, Will; Martin-Garcia, Julio et al. (2014) Defining differential genetic signatures in CXCR4- and the CCR5-utilizing HIV-1 co-linear sequences. PLoS One 9:e107389
Hu, Wenhui; Kaminski, Rafal; Yang, Fan et al. (2014) RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A 111:11461-6

Showing the most recent 10 out of 17 publications