The prevalence of mental health illness among patients with HIV is a significant public health issue. The translation of discoveries found at the bench to clinical practice (bench to bedside) is critical for advancements in diagnosing and therapeutic intervention to be made. This relationship, however, is not a one-way street, but bi-directional, where observations made in a clinical setting may also stimulate research at the bench. As such, it is important to develop a collaborative, multi-disciplinary community of clinicians and scientists to foster new discoveries with practical application in diagnosing and treating HIV+ persons with neuropsychological illness. To address this need, the Clinical and Behavioral Core will assist basic and clinical investigators wishing to include human subjects from a well-characterized cohort of HIV+ individuals in their studies, including those assessed for neuropsychological function. We will assist new and established investigators in the design and coordination of their studies, the preparation of required forms and approvals and data collection. To achieve this, the Clinical and Behavioral Core will have three primary functions: 1.) Provide the clinical cohort from the Temple Comprehensive HIV program with its infrastructure, operations management and regulatory oversight for clinical studies involving other CNACC cores or non-CNACC clinical collaborators, 2.) Systematically collect baseline and longitudinal neurocognitive, neurologic and psychiatric assessments on patients in Temple's HIV practice in collaboration with the Department of Psychiatry (for our revised application, we have included an expert neuropsychologist with HIV/AIDS neurocognitive testing and analysis experience, recently hired by Temple University Hospital (Dr. Nancy Minniti) and a consultant with internationally recognized expertise in neurocognitive testing, Dr. Kevin Robertson from the University of North Carolina.), and 3.) Develop and maintain a neurodatabase that will contain data from assessments in function #2, as well as relevant immunologic and virologic data from the Temple HIV clinical database and other studies conducted through CNACC.

Public Health Relevance

This core enables the integration of basic science investigations with clinical populations to further the aims of neuroscience translational research and expand opportunities for cross-disciplinary studies in epidemiology, public health and behavioral medicine. The core research activities foster the evaluation and application of novel targets and therapies in the management and care of HIV infected patients.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Special Emphasis Panel (ZMH1-ERB-F)
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Temple University
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Dampier, Will; Antell, Gregory C; Aiamkitsumrit, Benjamas et al. (2016) Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status. J Neurovirol :
Datta, Prasun K; Kaminski, Rafal; Hu, Wenhui et al. (2016) HIV-1 Latency and Eradication: Past, Present and Future. Curr HIV Res 14:431-441
Sariyer, Rahsan; De-Simone, Francesca Isabella; Gordon, Jennifer et al. (2016) Immune suppression of JC virus gene expression is mediated by SRSF1. J Neurovirol :
Kaminski, Rafal; Chen, Yilan; Fischer, Tracy et al. (2016) Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing. Sci Rep 6:22555
Regan, Patrick M; Sariyer, Ilker K; Langford, T Dianne et al. (2016) Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X Signaling. J Cell Physiol 231:1542-53
Zhong, Lin; Li, Hao; Li, Zhiqiang et al. (2016) C7 genotype of the donor may predict early bacterial infection after liver transplantation. Sci Rep 6:24121
Strazza, Marianne; Pirrone, Vanessa; Wigdahl, Brian et al. (2016) Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier. Int J Mol Sci 17:
Kaminski, R; Bella, R; Yin, C et al. (2016) Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study. Gene Ther 23:690-5
Wollebo, Hassen S; Bellizzi, Anna; Cossari, Dominique H et al. (2016) The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC. J Neurovirol 22:615-625
Feng, Dechun; Dai, Shen; Liu, Fengming et al. (2016) Cre-inducible human CD59 mediates rapid cell ablation after intermedilysin administration. J Clin Invest 126:2321-33

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