The Developmental Core will support the overall mission of the PMHARC by expanding the capacity and opportunity to conduct research on mental illness among HIV infected individuals. The services of the Core are designed to develop interest and expertise among early career investigators and transitional investigators who have not yet conducted research on mental illness and HIV. This will be accomplished via skills training, structured mentoring and support for four pilot projects to be initiated in each year of Center funding. In all of the Core's services, priority will be given to early career investigators and investigators from underrepresented racial and ethnic groups. The Developmental Core will provide monthly training seminars focused on research and grant writing skills development and, during the first year, on making the research community at Penn and CHOP aware of the services offered by the Center's four other shared resource Cores. The Core will also serve as a clearinghouse for related seminars and trainings being offered both on and off campus. A structured mentoring program implemented by the Developmental Core will focus on linking Junior and transitional investigators with established investigators in specific areas of mental health and AIDS research. The Core will provide guidance and training materials to assist mentors in their efforts to provide meaningful research and career development support to mentees. The pilot projects program for the Center will be administered by the Developmental Core. A rigorous review process will be implemented in order to select pilot projects that are scientifically sound, feasible and promote the overall mission of the Center. Each application will be assigned two internal and one external reviewer and a scoring system modeled after that used in NIH grant reviews will be used to assess scientific merit and programmatic relevance. All investigators selected for pilot funding will be required to have a designated mentor. The Core will maintain a service delivery database that will be used to evaluate success in delivering training, providing mentoring and reviewing and implementing pilot projects. We will also carefully track publications, grant applications, presentations and new collaborations that emerge from these Core services.

Public Health Relevance

The training, mentoring, and pilot funding delivered and managed by Core B will support the overall mission of the Center by expanding the number and capacity of investigators to conduct innovative and important mental health and AIDS research. By supporting promising pilot research the Core will initiate research programs that have real potential to improve the mental health and quality of life of HIV positive individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH097488-02
Application #
8670023
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$414,218
Indirect Cost
$155,332
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Dowshen, Nadia; Matone, Meredith; Luan, Xianqun et al. (2016) Behavioral and Health Outcomes for HIV+ Young Transgender Women (YTW) Linked To and Engaged in Medical Care. LGBT Health 3:162-7
Barrett, Jeffrey S; Spitsin, Sergei; Moorthy, Ganesh et al. (2016) Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. J Transl Med 14:148
Douglas, Steven D (2016) Substance P and sickle cell disease-a marker for pain and novel therapeutic approaches. Br J Haematol 175:187-188
Lyons, Anita; Bilker, Warren B; Hines, Janet et al. (2016) Effect of format on comprehension of adherence data in chronic disease: A cross-sectional study in HIV. Patient Educ Couns 99:154-9
McGuire, Jennifer L; Gill, Alexander J; Douglas, Steven D et al. (2016) The complement system, neuronal injury, and cognitive function in horizontally-acquired HIV-infected youth. J Neurovirol 22:823-830
Greeson, Jeffrey M; Gettes, David R; Spitsin, Sergei et al. (2016) The Selective Serotonin Reuptake Inhibitor Citalopram Decreases Human Immunodeficiency Virus Receptor and Coreceptor Expression in Immune Cells. Biol Psychiatry 80:33-9
McGuire, Jennifer L; Gill, Alexander J; Douglas, Steven D et al. (2015) Central and peripheral markers of neurodegeneration and monocyte activation in HIV-associated neurocognitive disorders. J Neurovirol 21:439-48
Springer, Sandra A; Larney, Sarah; Alam-Mehrjerdi, Zahra et al. (2015) Drug Treatment as HIV Prevention Among Women and Girls Who Inject Drugs From a Global Perspective: Progress, Gaps, and Future Directions. J Acquir Immune Defic Syndr 69 Suppl 2:S155-61
Yehia, Baligh R; Stephens-Shield, Alisa J; Momplaisir, Florence et al. (2015) Health Outcomes of HIV-Infected People with Mental Illness. AIDS Behav 19:1491-500
McGuire, Jennifer L; Kempen, John H; Localio, Russell et al. (2015) Immune markers predictive of neuropsychiatric symptoms in HIV-infected youth. Clin Vaccine Immunol 22:27-36

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