More than one-fourth of the adult population of the U.S. suffers from sleep disturbances now known to contribute to disability, morbidity and mortality. Sleep disturbance is entangled in chronic illnesses such as cardiovascular disease, diabetes and depression;in symptom clusters such as pain and fatigue;and as a consequence of obesity, life-style and work. The long term goal is to build a sustainable model research Center for Sleep-Related Symptom Science with a mission of increasing the conduct of high quality, innovative interdisciplinary biobehavioral sleep research. We propose to create a Center that will serve as a catalyst for investigators to develop the necessary expertise to undertake the measurement of sleep outcomes as well as a promoter of interdisciplinary collaboration and partnerships to enable sustainable growth in the conduct of sleep research.
The specific aims for this Center providing the framework to meet this mission are to: (1) provide a research infrastructure dedicated to sleep-related symptom science;(2) expand the number of research investigators involved in high quality, innovative interdisciplinary biobehavioral sleep research;and (3) enable sustainable growth in research programs prominently including sleep. Two cores, the Administrative Core and the Sleep Measurement Core, are proposed to implement the Center aims. Sustainability is accomplished by: (a) building cadre of translational and clinica researchers for whom sleep is the primary focus of their programs of research;(b) building a critical mass of investigators with sleep as a major variable of focus in their program of research;and (c) engaging investigators in which sleep disturbance is an important component in their program of research, e.g., cardiovascular disease and treatment-related sleep consequences. At the organizational level, sustainability is accomplished by the continuation and integration of Center activities into the organizational structure in the School of Nursing and the broader Johns Hopkins University community.

Public Health Relevance

Sleep is a fundamental physical need. Sleep disturbance is a major public health problem that both contributes to and is affected by illness, such as heart disease and diabetes. Sleep disturbance often co-occurs with other symptoms such as pain, fatigue and depression. The goal of the proposed Center is to expand the number of research investigators involved in high quality, innovative sleep research.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZNR1-REV-M (12))
Program Officer
Mccloskey, Donna J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Other Health Professions
Schools of Nursing
United States
Zip Code
Finan, Patrick H; Remeniuk, Bethany (2016) Is the brain reward system a mechanism of the association of sleep and pain? Pain Manag 6:5-8
Smith, Michael T; Finan, Patrick H; Buenaver, Luis F et al. (2015) Cognitive-behavioral therapy for insomnia in knee osteoarthritis: a randomized, double-blind, active placebo-controlled clinical trial. Arthritis Rheumatol 67:1221-33
Finan, Patrick H; Garland, Eric L (2015) The role of positive affect in pain and its treatment. Clin J Pain 31:177-87
Finan, Patrick H; Quartana, Phillip J; Smith, Michael T (2015) The Effects of Sleep Continuity Disruption on Positive Mood and Sleep Architecture in Healthy Adults. Sleep 38:1735-42
Quartana, Phillip J; Finan, Patrick H; Page, Gayle G et al. (2015) Effects of insomnia disorder and knee osteoarthritis on resting and pain-evoked inflammatory markers. Brain Behav Immun 47:228-37
Finan, Patrick H; Buenaver, Luis F; Coryell, Virginia T et al. (2014) Cognitive-Behavioral Therapy for Comorbid Insomnia and Chronic Pain. Sleep Med Clin 9:261-274
Finan, Patrick H; Zautra, Alex J (2013) Rheumatoid arthritis: stress affects rheumatoid arthritis, but via what mechanisms? Nat Rev Rheumatol 9:569-70