The Methods Core will provide infrastructure for advancing the science on cognitive/affective changes that accompany chronic illness and for ameliorating the symptoms associated with these changes using adaptive approaches and provider directed therapies (technical work). Cognitive/affective symptoms, so prevalent in chronic illness, are complex, multi-causal, non-linear and characterized by considerable variability. Thus, the methods for studying these symptoms must be able to characterize these aspects of the symptom experience for both groups and individuals. Trajectory science in nursing is expanding. Combined with longitudinal methods for both quantitative and qualitative data and innovative data visualization techniques, trajectory methods can be used to explore data in various ways to create different pictures of the phenomena and enhance insights that can be gained from studies of symptoms in chronic illness. The Methods Core will work closely with the Administrative Core and Scholarship/Mentoring Core to:
Aim 1 : Promote and expand bio-behavioral research and trajectory methods (longitudinal and longitudinal mixed methods designs, trajectory analyses, and visualization techniques) in studies to understand and ameliorate symptoms, symptom distress, and symptom sequelae for people with cognitive/affective changes in chronic illness.
Aim 2 : Provide consultation and support for trajectory methods.
Aim 3 : Support database development and management for Center Investigators.
Aim 4 : Collaborate with the Scholarship and Mentoring Core to promote learning and collaboration among center investigators through seminars and a journal club focused en measuring cognitive/affective symptoms and trajectory analyses.

Public Health Relevance

Cognitive/affective symptoms are common for patients with chronic illness. This Methods Core is to assist nursing scientists in conducting scientifically sound interdisciplinary research to advance symptom science.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
Center Core Grants (P30)
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Special Emphasis Panel (ZNR1-REV-M)
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Duke University
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Corazzini, Kirsten; Twersky, Jack; White, Heidi K et al. (2015) Implementing Culture Change in Nursing Homes: An Adaptive Leadership Framework. Gerontologist 55:616-27
Wu, Bei; Hybels, Celia; Liang, Jersey et al. (2014) Social stratification and tooth loss among middle-aged and older Americans from 1988 to 2004. Community Dent Oral Epidemiol 42:495-502
Corazzini, Kirsten N; Anderson, Ruth A (2014) Adaptive leadership and person-centered care: a new approach to solving problems. N C Med J 75:352-4
Carthron, Dana L; Bailey Jr, Donald E; Anderson, Ruth A (2014) The "invisible caregiver": multicaregiving among diabetic African-American grandmothers. Geriatr Nurs 35:S32-6
Amella, Elaine J; Batchelor-Aselage, Melissa B (2014) Facilitating ADLs by caregivers of persons with dementia: the C3P model. Occup Ther Health Care 28:51-61
Wei, Liang; Wu, Bei (2014) Racial and ethnic differences in obesity and overweight as predictors of the onset of functional impairment. J Am Geriatr Soc 62:61-70
Adams, Judith A; Bailey Jr, Donald E; Anderson, Ruth A et al. (2013) Finding your way through EOL challenges in the ICU using Adaptive Leadership behaviours: A qualitative descriptive case study. Intensive Crit Care Nurs 29:329-36