The proposed Center of Excellence (P30) will promote biobehavioral research to extend symptom science using the Adaptive Leadership (AL) framework to conceptualize and study cognitive/affective symptoms in chronic illness. The overall Center aims are to: (1) Enhance and sustain the productivity of new nursing scientists engaged in interdisciplinary biobehavioral research to understand and ameliorate symptoms, symptom distress, and symptom sequelae using adaptive approaches for people with cognitive/affective changes in chronic illness; (2) Assist investigators to tailor research approaches and interventions to optimize research participation by people with cognitive/affective changes by addressing minority health issues and refining existing, or creating new intervention protocols and self-report measures (i.e., Patient-Reported Outcomes Measurement Information System [PROMIS]. (3) Increase investigator competence in using longitudinal quantitative, qualitative, and mixed method approaches to examine the trajectories of symptoms, symptom sequelae and patient adaptation associated with cognitive/affective changes. The work of the Center will be carried by in three Cores, the Administrative Core, the Mentoring and Scholarship Core, and the Design and Methods Core. Expected outcomes of the center include studies of trajectories of cognitive/affective symptoms and symptom sequelae to describe patterns, variability, and change over time to gain knowledge needed about critical periods or transition points for timing of interventions, identify differences within subpopulatios such as those with varying levels of cognitive ability or minority health needs, and generate knowledge for developing/testing interventions to enhance patients'adaptive capabilities.

Public Health Relevance

Barriers to care arise for people with cognitive/affective changes because they may not clearly convey concerns or communicate easily. If not addressed through research, these barriers will create health disparities. Center researchers will study trajectories of cognitive/affective symptoms and symptom sequelae to gain knowledge needed for developing tailored interventions and enhance care for these populations.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZNR1)
Program Officer
Mccloskey, Donna J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Schools of Nursing
United States
Zip Code
Corazzini, Kirsten; Twersky, Jack; White, Heidi K et al. (2015) Implementing Culture Change in Nursing Homes: An Adaptive Leadership Framework. Gerontologist 55:616-27
Wu, Bei; Hybels, Celia; Liang, Jersey et al. (2014) Social stratification and tooth loss among middle-aged and older Americans from 1988 to 2004. Community Dent Oral Epidemiol 42:495-502
Corazzini, Kirsten N; Anderson, Ruth A (2014) Adaptive leadership and person-centered care: a new approach to solving problems. N C Med J 75:352-4
Carthron, Dana L; Bailey Jr, Donald E; Anderson, Ruth A (2014) The "invisible caregiver": multicaregiving among diabetic African-American grandmothers. Geriatr Nurs 35:S32-6
Amella, Elaine J; Batchelor-Aselage, Melissa B (2014) Facilitating ADLs by caregivers of persons with dementia: the C3P model. Occup Ther Health Care 28:51-61
Wei, Liang; Wu, Bei (2014) Racial and ethnic differences in obesity and overweight as predictors of the onset of functional impairment. J Am Geriatr Soc 62:61-70
Adams, Judith A; Bailey Jr, Donald E; Anderson, Ruth A et al. (2013) Finding your way through EOL challenges in the ICU using Adaptive Leadership behaviours: A qualitative descriptive case study. Intensive Crit Care Nurs 29:329-36