CORE B: GENETICS CORE The purpose of this Core is to provide support for transgenic mouse and zebrafish research. This Core will facilitate current NINDS-funded research and stimulate synergistic Interactions between diverse Investigators using different animal model systems. This support will benefit all investigators by subsidizing costs and providing advanced genome editing services and aquaculture services. The Genetics Core has two components, each with its own faculty Director. I. Transgenic Mice Core Overview The aim of this Core is to support the development of novel mouse models that will facilitate NINDS-funded researchers and stimulate synergistic interactions between Pis in the OSU Neuroscience Center. Because the Core will subsidize the cost of making transgenic and knockout mice, it will support new investigators to develop mouse models which otherwise could be cost prohibitive. This support will be provided by subsidizing costs of generating transgenic and knockout mouse lines and subsidizing the per diems during the initial expansion and characterization phase of the mouse line. Over the 4.5 years of the grant 43 transgenic mice were generated using Core Support benefiting four Pis (Oberdick, Burghes, Obrietan, Yoon). This Core component was cited in twelve papers and led to two new R01s. The projected need for the renewal is forty two transgenics and ten knock outs benefiting ten Pis. Thus, this is a valued, productive Core.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Meisen, Walter Hans; Dubin, Samuel; Sizemore, Steven T et al. (2015) Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies. Mol Cancer Ther 14:307-14
Bolyard, Chelsea; Yoo, Ji Young; Wang, Pin-Yi et al. (2014) Doxorubicin synergizes with 34.5ENVE to enhance antitumor efficacy against metastatic ovarian cancer. Clin Cancer Res 20:6479-94
Koemeter-Cox, Andrew I; Sherwood, Thomas W; Green, Jill A et al. (2014) Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons. Proc Natl Acad Sci U S A 111:10335-40
Biswas, Sayantanee; Emond, Michelle R; Duy, Phan Q et al. (2014) Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish. Mol Biol Cell 25:633-42
Tian, JinBin; Tep, Chhavy; Benedick, Alex et al. (2014) p75 regulates Purkinje cell firing by modulating SK channel activity through Rac1. J Biol Chem 289:31458-72
Wojton, Jeffrey; Meisen, Walter Hans; Jacob, Naduparambil K et al. (2014) SapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma. Oncotarget 5:9703-9
Janssen, Paul M L; Murray, Jason D; Schill, Kevin E et al. (2014) Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy. PLoS One 9:e88360
Nielson, Jessica L; Guandique, Cristian F; Liu, Aiwen W et al. (2014) Development of a database for translational spinal cord injury research. J Neurotrauma 31:1789-99
Thorne, Amy Haseley; Meisen, Walter H; Russell, Luke et al. (2014) Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance. Mol Ther 22:1678-87
Sahinkaya, F Rezan; Milich, Lindsay M; McTigue, Dana M (2014) Changes in NG2 cells and oligodendrocytes in a new model of intraspinal hemorrhage. Exp Neurol 255:113-26

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