This Core has two related components that offer different services. The CNS/PNS Injury Core will provide technical support to generate animal models of Injury and to characterize their behavioral impairment after injury. The Rodent Behavior Core will provide services to test rodent models in standard behavioral paradigms. This Core component also synergizes with the Genetics Core and provides a mechanism to analyze the behavior of transgenic and knockout mice. I. CNS/PSN Nerve Injury Core Overview The study of CNS/PNS nerve Injury is a major strength on the OSU campus. With the services available in this Core, NINDS funded investigators will be able to greatly expand the scope of their work by having easy access to an array of surgical and behavioral techniques which are not typically located together in a single laboratory. This Core will also provide the ability to test novel agents in CNS/PNS Injury models. During the current award nine Pis used this Core resulting in sixteen papers and one new R01.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Ohio State University
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Welker, Alessandra M; Jaros, Brian D; Puduvalli, Vinay K et al. (2016) Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity. Dis Model Mech 9:199-210
Yoo, Ji Young; Jaime-Ramirez, Alena Cristina; Bolyard, Chelsea et al. (2016) Bortezomib Treatment Sensitizes Oncolytic HSV-1-Treated Tumors to NK Cell Immunotherapy. Clin Cancer Res 22:5265-5276
Borniger, Jeremy C; Cissé, Yasmine M; Cantemir-Stone, Carmen Z et al. (2016) Behavioral abnormalities in mice lacking mesenchyme-specific Pten. Behav Brain Res 304:80-5
Green, Jill A; Schmid, Cullen L; Bley, Elizabeth et al. (2016) Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization. Mol Cell Biol 36:223-35
Ru, Peng; Hu, Peng; Geng, Feng et al. (2016) Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth. Cell Rep 16:1527-35
Hansen, Katelin F; Sakamoto, Kensuke; Aten, Sydney et al. (2016) Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome. Learn Mem 23:61-71
Church, Jamie S; Kigerl, Kristina A; Lerch, Jessica K et al. (2016) TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord. J Neurosci 36:6352-64
Lowe, Jeovanna; Floyd, Kyle T; Rastogi, Neha et al. (2016) Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice. J Neuromuscul Dis 3:395-404
Gygli, Patrick E; Chang, Joshua C; Gokozan, Hamza N et al. (2016) Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (Albany NY) 8:1540-70
Saad, Nancy S; Floyd, Kyle; Ahmed, Amany A E et al. (2016) The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities. PLoS One 11:e0153694

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