Abstract

Administrative Organization. There will be three levels of oversight, including: the PSO Directors and Core Directors/Co-Directors to monitor ongoing activities and to interface with users; a Steering committee to review operating procedures and activity reports on an annual basis, as well as to advise on prioritization issues and core effectiveness; and an Advisory Board to offer advice on technology updates and management issues. This organizational structure will be logistically supported by an Administrative Core with a dedicated senior grants manager to assure compliance at all levels. Collectively, this administrative organization will be responsible for ensuring adherence to NINDS Program guidelines; implementing a fair and equitable Core utilization plan; monitoring Core functions, performance, accessibility and user satisfaction; implementing upgrades; securing institutional support and maintaining effective financial administration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS045776-11A1
Application #
8731689
Study Section
Special Emphasis Panel (ZNS1-SRB-B (38))
Project Start
Project End
Budget Start
2015-01-15
Budget End
2015-11-30
Support Year
11
Fiscal Year
2015
Total Cost
$75,206
Indirect Cost
$31,984

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Pagnier, Guillaume J; Kastanenka, Ksenia V; Sohn, Miwon et al. (2018) Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimers Res Ther 10:11
Jorfi, Mehdi; D'Avanzo, Carla; Kim, Doo Yeon et al. (2018) Three-Dimensional Models of the Human Brain Development and Diseases. Adv Healthc Mater 7:
Landeira, Bruna Soares; Santana, Themis Taynah da Silva; Araújo, Jéssica Alves de Medeiros et al. (2018) Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development. Cereb Cortex 28:538-548
György, Bence; Cruz, Lilian; Yellen, David et al. (2018) Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts. Sci Rep 8:2324
DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin et al. (2018) Tau reduction in the presence of amyloid-? prevents tau pathology and neuronal death in vivo. Brain 141:2194-2212
Teng, Jian; Hejazi, Seyedali; Hiddingh, Lotte et al. (2018) Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype. Neuro Oncol 20:642-654
Kovalenko, Marina; Milnerwood, Austen; Giordano, James et al. (2018) HttQ111/+ Huntington's Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. J Huntingtons Dis 7:17-33
Jorfi, Mehdi; D'Avanzo, Carla; Tanzi, Rudolph E et al. (2018) Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Sci Rep 8:2450
György, Bence; Sage, Cyrille; Indzhykulian, Artur A et al. (2017) Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV. Mol Ther 25:379-391
Maesako, Masato; Horlacher, Jana; Zoltowska, Katarzyna M et al. (2017) Pathogenic PS1 phosphorylation at Ser367. Elife 6:

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