The Neuroscience Neuroimaging Center (NNC) NINDS PSO Institutional Center Core was established in 2003 to provide researchers at the University of Pennsylvania and later collaborating institutions with access to multidisciplinary expertise in neuroimaging research. This NINDS PSO Center Core consolidates a broad range of methodological expertise in neuroimaging to create a community of investigators focused on the application of advanced neuroimaging methods to neuroscience research who work together to optimize resource utilization and provide users with access to the latest methodologies for image acquisition and analysis. This centralization of methodological expertise has improved the quality and scope of neuroimaging methodologies available, and has reduced the cost of individual grant proposals, which would otherwise need to include much or all of their required expertise within their specific project budgets. An Administrative Core provides oversight for the Center, administrative support for its resources, regulatory support for its users, and is guided by a Steering Committee comprised of Core Directors, consortium representatives, and user representatives. An Acquisition Core provides technical support for magnetic resonance and optical imaging protocol development and implementation, imaging quality assurance, and for implementing capabilities for stimulus delivery and biobehavioral response monitoring. An Analysis Core supports structural morphometry, diffusion tensor tractography, localized and global brain segmentation, image visualization, statistical modeling, and genomic analyses by providing both general tools and customized data processing pipelines. An Informatics Core maintains a state-of-the-art data processing environment with access to a broad range of image analysis software, data storage and archiving, and system administration support for both core computing and users. A consortium consisting of the University of Pennsylvania (Penn), Children's Hospital of Philadelphia (CHOP), and the Moss Rehabilitation Research Institute (MRRI) in Philadelphia with the NNC currently includes 15 investigators with qualifying NINDS grants along with numerous other basic and clinical neuroscientists working within the NINDS mission who use the Core.
The Neuroscience Neuroimaging Center consolidates resources and expertise in neuroimaging at the University of Pennsylvania to provide infrastructure support for both preclinical and clinical research relevant to the NINDS mission to reduce the burden of neurological disease. Center users carry out a broad range of research in disorders such as stroke, epilepsy, migraine, traumatic brain injury, degenerative diseases of the brain, and developmental disorders.
|Kandel, Benjamin M; Wang, Danny J J; Gee, James C et al. (2015) Eigenanatomy: sparse dimensionality reduction for multi-modal medical image analysis. Methods 73:43-53|
|Benson, Noah C; Butt, Omar H; Brainard, David H et al. (2014) Correction of distortion in flattened representations of the cortical surface allows prediction of V1-V3 functional organization from anatomy. PLoS Comput Biol 10:e1003538|
|Boylan, Christine; Trueswell, John C; Thompson-Schill, Sharon L (2014) Multi-voxel pattern analysis of noun and verb differences in ventral temporal cortex. Brain Lang 137:40-9|
|Woo, John H; Wang, Sumei; Melhem, Elias R et al. (2014) Linear associations between clinically assessed upper motor neuron disease and diffusion tensor imaging metrics in amyotrophic lateral sclerosis. PLoS One 9:e105753|
|Favilla, Christopher G; Mesquita, Rickson C; Mullen, Michael et al. (2014) Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation. Stroke 45:1269-74|
|Cucchiara, Brett; Wolf, Ronald L; Nagae, Lidia et al. (2013) Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study. PLoS One 8:e71007|
|Goldman, Marina; Szucs-Reed, Regina P; Jagannathan, Kanchana et al. (2013) Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects. J Addict Med 7:8-16|
|Zheng, Yuanjie; Lin, Stephen; Kang, Sing Bing et al. (2013) Single-image vignetting correction from gradient distribution symmetries. IEEE Trans Pattern Anal Mach Intell 35:1480-94|
|Lawson, Gwendolyn M; Duda, Jeffrey T; Avants, Brian B et al. (2013) Associations between children's socioeconomic status and prefrontal cortical thickness. Dev Sci 16:641-52|
|Butt, Omar H; Benson, Noah C; Datta, Ritobrato et al. (2013) The fine-scale functional correlation of striate cortex in sighted and blind people. J Neurosci 33:16209-19|
Showing the most recent 10 out of 128 publications