Neuroimaging methods are increasingly applied to all phases of neuroscience research ranging from preclinical studies in animal models to human patients. Even in an era of genomics and molecular medicine, neuroimaging remains essential for phenotyping brain structure and function, and for monitoring the evolution of brain disorders and their treatments. However, neuroimaging methodologies are constantly evolving, and their optimal use requires specialized methodological expertise. The Acquisition Core consolidates expertise in neuroimaging physics and engineering at the University of Pennsylvania to support a broad range of imaging methodologies relevant to the NINDS mission to reduce the burden of neurological disease. The primary supported acquisition strategy is MRI, which provides multiple contrast mechanisms relevant to brain structure and function. For this, the Acquisition Core leverages the availability of multiple research MRI systems at the University of Pennsylvania including human whole-body MRI systems operating at 3 Tesla and 7 Tesla and animal MRI systems operating at 3 Tesla, 4.7 Tesla and 9.4 Tesla. The Acquisition Core also supports optical imaging and transcranial magnetic stimulation (TMS) as well as a range of ancillary instrumentation used for stimulus delivery and biobehavioral response monitoring during neuroimaging. Supported technical expertise is used to provide consultation concerning specific imaging modalities, to implement new or improved imaging strategies, to provide troubleshooting and quality assurance for image artifacts, and to collaborate on multimodal image acquisition protocols. NNC users benefit from simplified access to methodological consultations and consolidation of technical expertise also improves efficiency and reduces the cost of neuroimaging research since most technical problems need not be solved separately for each project. Accordingly, neuroimaging application projects do not need to budget for extensive methodological support. Finally, consolidation of technical expertise fosters a highly collaborative environment for both Core personnel and Core users leading tonew approaches and research directions and rapid dissemination of methodological advances to the entire user community

Public Health Relevance

Neuroimaging allows noninvasive assessment of brain structure and function and is an important research tool for both preclinical and clinical studies. The Acquisition Core provides expertise in the implementation and use of neuroimaging methods s to investigators working within the NINDS mission to reduce the burden of neurological disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS045839-11A1
Application #
8783805
Study Section
Special Emphasis Panel (ZNS1-SRB-B (38))
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
11
Fiscal Year
2014
Total Cost
$218,795
Indirect Cost
$72,673
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kandel, Benjamin M; Wang, Danny J J; Gee, James C et al. (2015) Eigenanatomy: sparse dimensionality reduction for multi-modal medical image analysis. Methods 73:43-53
Benson, Noah C; Butt, Omar H; Brainard, David H et al. (2014) Correction of distortion in flattened representations of the cortical surface allows prediction of V1-V3 functional organization from anatomy. PLoS Comput Biol 10:e1003538
Boylan, Christine; Trueswell, John C; Thompson-Schill, Sharon L (2014) Multi-voxel pattern analysis of noun and verb differences in ventral temporal cortex. Brain Lang 137:40-9
Woo, John H; Wang, Sumei; Melhem, Elias R et al. (2014) Linear associations between clinically assessed upper motor neuron disease and diffusion tensor imaging metrics in amyotrophic lateral sclerosis. PLoS One 9:e105753
Favilla, Christopher G; Mesquita, Rickson C; Mullen, Michael et al. (2014) Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation. Stroke 45:1269-74
Cucchiara, Brett; Wolf, Ronald L; Nagae, Lidia et al. (2013) Migraine with aura is associated with an incomplete circle of willis: results of a prospective observational study. PLoS One 8:e71007
Goldman, Marina; Szucs-Reed, Regina P; Jagannathan, Kanchana et al. (2013) Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects. J Addict Med 7:8-16
Zheng, Yuanjie; Lin, Stephen; Kang, Sing Bing et al. (2013) Single-image vignetting correction from gradient distribution symmetries. IEEE Trans Pattern Anal Mach Intell 35:1480-94
Lawson, Gwendolyn M; Duda, Jeffrey T; Avants, Brian B et al. (2013) Associations between children's socioeconomic status and prefrontal cortical thickness. Dev Sci 16:641-52
Butt, Omar H; Benson, Noah C; Datta, Ritobrato et al. (2013) The fine-scale functional correlation of striate cortex in sighted and blind people. J Neurosci 33:16209-19

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