&

Public Health Relevance

The Bioinformatics Core represents a new initiative for this renewal of the Center grant, taking the place of the Expression Profiling (Affyrrietrix) 'Core facility, which is now self-sustaining. The proposed Bioinformatics Core will facilitate the use of massively parallel sequencing (MPS) techniques, by providing neuroscientists with a dedicated bioinformatician. This Core will also serve as a repository of expertise for NINDS-funded and other UNC neuroscience faculty, particularly with regard to the design of MPS experiments, analysis of data, and use of existing MPS infrastructure at UNC-Chapel Hill. Since this level of bioinformatics support is also needed by neuroscientists in the Carolina Institute for Developmental Disabilities (ClOD), this Core will jointly be supported (50:50) by this NINDS Center grant and by ClOD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS045892-11
Application #
8791163
Study Section
Special Emphasis Panel (ZNS1-SRB-R (59))
Project Start
Project End
Budget Start
2014-02-01
Budget End
2014-11-30
Support Year
11
Fiscal Year
2014
Total Cost
$53,256
Indirect Cost
$18,219
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Pearson, Brandon L; Simon, Jeremy M; McCoy, Eric S et al. (2016) Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nat Commun 7:11173
Zhou, Zhe Charles; Yu, Chunxiu; Sellers, Kristin K et al. (2016) Dorso-Lateral Frontal Cortex of the Ferret Encodes Perceptual Difficulty during Visual Discrimination. Sci Rep 6:23568
Mabb, Angela M; Simon, Jeremy M; King, Ian F et al. (2016) Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS One 11:e0156439
Pinto, Maria J; Alves, Pedro L; Martins, Luís et al. (2016) The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates. J Cell Biol 212:789-801
Yu, Chunxiu; Sellers, Kristin K; Radtke-Schuller, Susanne et al. (2016) Structural and functional connectivity between the lateral posterior-pulvinar complex and primary visual cortex in the ferret. Eur J Neurosci 43:230-44
Kim, Hyojin; Kunz, Portia A; Mooney, Richard et al. (2016) Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. J Neurosci 36:4888-94
Jones, Kelly A; Han, Ji Eun; DeBruyne, Jason P et al. (2016) Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice. Sci Rep 6:28238
Crowley, Nicole A; Bloodgood, Daniel W; Hardaway, J Andrew et al. (2016) Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep 14:2774-83
Fox, Megan E; Bucher, Elizabeth S; Johnson, Justin A et al. (2016) Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis. ACS Chem Neurosci 7:1681-1689
Stirman, Jeffrey N; Smith, Ikuko T; Kudenov, Michael W et al. (2016) Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain. Nat Biotechnol 34:857-62

Showing the most recent 10 out of 125 publications