Abstract

D3.1. Rationale and Mission. The goal of the Computational Genomics Core is to provide bioinformatics supportand advanced genomics tools to neuroscientists at Tufts University and its affiliated institutions. During thefirst 1.5 years of the grant cycle, the core provided basic bioinformatics support to neuroscientists. The growingneed for both more sophisticated analytic tools and high throughput genomic technologies led to an expansionof the core over the past 2 years. Partnership with other Tufts Centers - the GRASP gastroenterology centerand the Molecular Cardiology Research Institute (MCRI) - enabled the CNR to expand the bioinformatics consultationteam as well as provide selected genomics services, including real-time RT-PCR and gene microarrayanalysis. The computational genomics team is currently led by a PhD-level computational biologist, Dr. LaxIyer and includes Mr. Christopher Parkin, who performs data analysis and consultation, and Ms. Yue Shao whosupervises the real-time PCR (Q-PCR) service and performs microarray experiments for neuroscientists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS047243-06
Application #
7674146
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2008-08-01
Project End
2013-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
6
Fiscal Year
2008
Total Cost
$250,463
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Kulkarni, Shreya; Goel-Bhattacharya, Surbhi; Sengupta, Sejuti et al. (2018) A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. Mol Cancer Res 16:103-114
You, Samantha; Fulga, Tudor A; Van Vactor, David et al. (2018) Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. Genetics 208:1195-1207
Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka et al. (2018) MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy :1-4
Dickson, David A; Paulus, Jessica K; Mensah, Virginia et al. (2018) Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress. Transl Psychiatry 8:101
Xu, Jie; Bartolome, Christopher L; Low, Cho Shing et al. (2018) Genetic identification of leptin neural circuits in energy and glucose homeostases. Nature 556:505-509
Chen, Zhigang; Li, Wenlu; Qiu, Fuming et al. (2018) Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. Theranostics 8:4447-4461
Melón, Laverne Camille; Hooper, Andrew; Yang, Xuzhong et al. (2018) Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology 90:182-193
Kim, WonHee; Ma, Liang; Lomoio, Selene et al. (2018) BACE1 elevation engendered by GGA3 deletion increases ?-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener 13:6
Cai, Weikang; Xue, Chang; Sakaguchi, Masaji et al. (2018) Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest 128:2914-2926
Shaban, Lamyaa; Chen, Ying; Fasciano, Alyssa C et al. (2018) A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50:85-92

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