D4.1. Rationale and Mission. The development of molecular and genetic technologies by neuroscientists has increased the need to examine the effects of in vitro mutations within the intact and functioning animal. Functional analysis of behavior is also required to study the molecular consequences of many modeled neurological and psychiatric disorders for which changes in gene expression and neurochemistry in the brain correlate with behavioral alterations. Comprehensive behavioral phenotyping, however, often requires expertise and instrumentation beyond the financial and technical capabilities of most individual laboratories. Thus, shared behavioral facilities need to be crucial components of university research core facilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047243-09
Application #
8374498
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
9
Fiscal Year
2012
Total Cost
$102,399
Indirect Cost
$40,339
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Mukherjee, Jayanta; Cardarelli, Ross A; Cantaut-Belarif, Yasmine et al. (2017) Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proc Natl Acad Sci U S A 114:11763-11768
Khayat, A; Monteiro, N; Smith, E E et al. (2017) GelMA-Encapsulated hDPSCs and HUVECs for Dental Pulp Regeneration. J Dent Res 96:192-199
Felsted, Jennifer A; Chien, Cheng-Hao; Wang, Dongqing et al. (2017) Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis. Cell Rep 21:2737-2747
Salzberg, Yehuda; Coleman, Andrew J; Celestrin, Kevin et al. (2017) Reduced Insulin/Insulin-Like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Sensor IRE-1. PLoS Genet 13:e1006579
Urra, Félix A; Muñoz, Felipe; Lovy, Alenka et al. (2017) The Mitochondrial Complex(I)ty of Cancer. Front Oncol 7:118
Morel, Lydie; Chiang, Ming Sum R; Higashimori, Haruki et al. (2017) Molecular and Functional Properties of Regional Astrocytes in the Adult Brain. J Neurosci 37:8706-8717
Papouin, Thomas; Dunphy, Jaclyn M; Tolman, Michaela et al. (2017) Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron 94:840-854.e7
Bustos, Galdo; Cruz, Pablo; Lovy, Alenka et al. (2017) Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target. Front Oncol 7:199
Hawley, Dillon; Ding, Jian; Thotakura, Suharika et al. (2017) RNA-Seq and CyTOF immuno-profiling of regenerating lacrimal glands identifies a novel subset of cells expressing muscle-related proteins. PLoS One 12:e0179385
Herwald, Sanna E; Zucchi, Paola C; Tan, Shumin et al. (2017) The two transmembrane regions of Candida albicans Dfi1 contribute to its biogenesis. Biochem Biophys Res Commun 488:153-158

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