D4.1. Rationale and Mission. The development of molecular and genetic technologies by neuroscientists has increased the need to examine the effects of in vitro mutations within the intact and functioning animal. Functional analysis of behavior is also required to study the molecular consequences of many modeled neurological and psychiatric disorders for which changes in gene expression and neurochemistry in the brain correlate with behavioral alterations. Comprehensive behavioral phenotyping, however, often requires expertise and instrumentation beyond the financial and technical capabilities of most individual laboratories. Thus, shared behavioral facilities need to be crucial components of university research core facilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047243-09
Application #
8374498
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
9
Fiscal Year
2012
Total Cost
$102,399
Indirect Cost
$40,339
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Park, Kellie A; Ribic, Adema; Laage Gaupp, Fabian M et al. (2016) Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. J Neurosci 36:7464-75
Chen, Wei-Sheng; Cao, Zhiyi; Sugaya, Satoshi et al. (2016) Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun 7:11302
Cárdenas, César; Müller, Marioly; McNeal, Andrew et al. (2016) Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria. Cell Rep 14:2313-24
Armbruster, Moritz; Hanson, Elizabeth; Dulla, Chris G (2016) Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. J Neurosci 36:10404-10415
Hanson, Elizabeth; Danbolt, Niels Christian; Dulla, Chris G (2016) Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust. Neurobiol Dis 89:157-68
Walker, Kendall R; Modgil, Amit; Albrecht, David et al. (2016) Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission. PLoS One 11:e0155799
Yeates, Eniola Funmilayo Aduke; Tesco, Giuseppina (2016) The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation. J Biol Chem 291:15753-66
Zhao, Jin; Schnitzler, Gavin R; Iyer, Lakshmanan K et al. (2016) MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation. PLoS One 11:e0156772
Hooper, Andrew; Maguire, Jamie (2016) Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus 26:41-53
Lee, Vallent; MacKenzie, Georgina; Hooper, Andrew et al. (2016) Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus 26:1276-90

Showing the most recent 10 out of 150 publications