D3.1. Rationale and Mission. The goal of the Computational Genomics Core is to provide bioinformatics support and advanced genomics tools to neuroscientists at Tufts University and its affiliated institutions. During the first 1.5 years of the grant cycle, the core provided basic bioinformatics support to neuroscientists. The growing need for both more sophisticated analytic tools and high throughput genomic technologies led to an expansion of the core over the past 2 years. Partnership with other Tufts Centers - the GRASP gastroenterology center and the Molecular Cardiology Research Institute (MCRI) - enabled the CNR to expand the bioinformatics consultation team as well as provide selected genomics services, including real-time RT-PCR and gene microarray analysis. The computational genomics team is currently led by a PhD-level computational biologist, Dr. Lax Iyer and includes Mr. Christopher Parkin, who performs data analysis and consultation, and Ms. Yue Shao who supervises the real-time PCR (Q-PCR) service and performs microarray experiments for neuroscientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047243-10
Application #
8441553
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
10
Fiscal Year
2013
Total Cost
$236,012
Indirect Cost
$92,975
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Mukherjee, Jayanta; Cardarelli, Ross A; Cantaut-Belarif, Yasmine et al. (2017) Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proc Natl Acad Sci U S A 114:11763-11768
Khayat, A; Monteiro, N; Smith, E E et al. (2017) GelMA-Encapsulated hDPSCs and HUVECs for Dental Pulp Regeneration. J Dent Res 96:192-199
Felsted, Jennifer A; Chien, Cheng-Hao; Wang, Dongqing et al. (2017) Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis. Cell Rep 21:2737-2747
Salzberg, Yehuda; Coleman, Andrew J; Celestrin, Kevin et al. (2017) Reduced Insulin/Insulin-Like Growth Factor Receptor Signaling Mitigates Defective Dendrite Morphogenesis in Mutants of the ER Stress Sensor IRE-1. PLoS Genet 13:e1006579
Urra, Félix A; Muñoz, Felipe; Lovy, Alenka et al. (2017) The Mitochondrial Complex(I)ty of Cancer. Front Oncol 7:118
Morel, Lydie; Chiang, Ming Sum R; Higashimori, Haruki et al. (2017) Molecular and Functional Properties of Regional Astrocytes in the Adult Brain. J Neurosci 37:8706-8717
Papouin, Thomas; Dunphy, Jaclyn M; Tolman, Michaela et al. (2017) Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron 94:840-854.e7
Bustos, Galdo; Cruz, Pablo; Lovy, Alenka et al. (2017) Endoplasmic Reticulum-Mitochondria Calcium Communication and the Regulation of Mitochondrial Metabolism in Cancer: A Novel Potential Target. Front Oncol 7:199
Hawley, Dillon; Ding, Jian; Thotakura, Suharika et al. (2017) RNA-Seq and CyTOF immuno-profiling of regenerating lacrimal glands identifies a novel subset of cells expressing muscle-related proteins. PLoS One 12:e0179385
Herwald, Sanna E; Zucchi, Paola C; Tan, Shumin et al. (2017) The two transmembrane regions of Candida albicans Dfi1 contribute to its biogenesis. Biochem Biophys Res Commun 488:153-158

Showing the most recent 10 out of 200 publications