Electrophysiological data are often considered the gold standard for demonstrating a causal relationship between cell/circuit physiology and behavior. Generating preliminary data is a daunting prospect, however, for an investigator who lacks the years of training necessary to produce a competent, independent electrophysiologist. Electrophysiological studies also require a considerable up-front investment in personnel and equipment, further discouraging investigators from entering the electrophysiological arena. When the EBC was first established, the electrophysiology community at Tufts was small (Cox and Dunlap being the only electrophysiologists on the faculty), yet there were significant numbers of faculty seeking to bring electrophysiological approaches to bear on their research projects. The EBC was, thus, established to promote more widespread use of electrophysiology in neuroscience research laboratories at Tufts. This mission has been realized more completely than we thought possible (see C5.2.3i for details). Tufts'electrophysiology community has changed dramatically since the CNR was established in 2003, in part due to the success of the EBC. Several investigators received their introduction to electrophysiology in the EBC. Remarkably, four of these (Feig, Galper, Jacob, Rios) now have students and/or fellows in their labs who independently perform such experiments on setups in their own labs or in the EBC. In addition, the recent Neuroscience Department expansion has further changed the demographics of CNR users. Electrophysiological recording is now key in the labs of Cox, Dunlap, Dulla, Feig, Galper, Haydon, Jacob, Maguire, Moss, Rios, and Trimmer. With this growth of the electrophysiology community, (i) the number of users needing access to EBC's existing setups is approaching a steady-state, (ii) the majority of EBC users are sufficiently trained to not only carry out their experiments independently, but to help train future lab personnel, and (iii) there is increasing demand for in vivo stimulation/recording as programs adopt a more behavioral focus. This evolution is driving changes in the EBC (described below) to allow us to continue to meet the electrophysiological needs of the Tufts neuroscience community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS047243-11
Application #
8787523
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2014-02-01
Project End
2018-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111
You, Samantha; Fulga, Tudor A; Van Vactor, David et al. (2018) Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. Genetics 208:1195-1207
Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka et al. (2018) MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy :1-4
Dickson, David A; Paulus, Jessica K; Mensah, Virginia et al. (2018) Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress. Transl Psychiatry 8:101
Xu, Jie; Bartolome, Christopher L; Low, Cho Shing et al. (2018) Genetic identification of leptin neural circuits in energy and glucose homeostases. Nature 556:505-509
Chen, Zhigang; Li, Wenlu; Qiu, Fuming et al. (2018) Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. Theranostics 8:4447-4461
Melón, Laverne Camille; Hooper, Andrew; Yang, Xuzhong et al. (2018) Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology 90:182-193
Kim, WonHee; Ma, Liang; Lomoio, Selene et al. (2018) BACE1 elevation engendered by GGA3 deletion increases ?-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener 13:6
Cai, Weikang; Xue, Chang; Sakaguchi, Masaji et al. (2018) Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest 128:2914-2926
Shaban, Lamyaa; Chen, Ying; Fasciano, Alyssa C et al. (2018) A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50:85-92
Hooper, Andrew; Paracha, Rumzah; Maguire, Jamie (2018) Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors. Epilepsy Behav 78:124-133

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