The Behavioral Assessment Core is housed in the Zeigler Research Building (ZRB) on the 9'*^ floor, close to the offices and laboratories of both Drs. Wyss and van Groen. The Core occupies approximately 2000 gross square feet of approved animal care space. Three rooms in the Core area will provide for the temporary housing of animals during the testing. A designated room is used for housing the animals in the period immediately before (1 week to 2 days) and during the testing period. There are two rooms for individual behavioral tests and a separate room for data analysis. The individual rooms are described in detail below. The Mouse Behavioral Testing Laboratory is within the Zeigler BIdg. rooms 945 and 941;ZRB 936 is used for housing mice during the testing period. Please note that there are 2 rooms for individual behavioral tests and another data analysis room in Tinsley Harhson Tower 966, next to Dr. van Groen's office). The individual rooms are described in detail below. The Behavioral Assessment Core area in ZRB Room 945 is divided into five assessment areas for evaluation of (1) SHIRPA/motor coordination and skill learning;(2) water maze learning;(3) Barnes maze learning (exchangeable with eight-arm radial maze);(4) open field and elevated plus maze and (5) 24 h activity levels. The """"""""Water Maze Area"""""""" houses the water maze spatial memory test. The water maze is a 'water'exploratory task used to study spatial and cued memory. In this task, mice learn to locate an escape platform hidden under the water line of the pool to escape the water. The pool used is from San Diego Instruments. A Noldus tracking system (Noldus Information Technology Inc. Leesburg, VA) is used to quantify the exploratory behavior of mice. The water maze is available as part of the learning and memory module and is the standard"""""""" spatial learning task. We also have an """"""""8-arm"""""""" insert for the water maze to convert it into a """"""""wet"""""""" version of the 8-arm maze task.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Qin, Hongwei; Buckley, Jessica A; Li, Xinru et al. (2016) Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration. J Neurosci 36:5144-59
Jansone, Baiba; Kadish, Inga; van Groen, Thomas et al. (2016) Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice. Pharmacol Res 113:781-787
Heaven, Michael R; Flint, Daniel; Randall, Shan M et al. (2016) Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease. J Proteome Res 15:2265-82
Dieni, Cristina V; Panichi, Roberto; Aimone, James B et al. (2016) Low excitatory innervation balances high intrinsic excitability of immature dentate neurons. Nat Commun 7:11313
Kadish, Inga; Kumar, Ashish; Beitnere, Ulrika et al. (2016) Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice. Exp Gerontol 86:39-49
Patel, Preeyam S; King, R Glenn; Kearney, John F (2016) Pulmonary α-1,3-Glucan-Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy. J Immunol 197:3175-3187
Lavalley, Nicholas J; Slone, Sunny R; Ding, Huiping et al. (2016) 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. Hum Mol Genet 25:109-22
Kumar, Ashish; Zhang, Jennifer; Tallaksen-Greene, Sara et al. (2016) Allelic series of Huntington's disease knock-in mice reveals expression discorrelates. Hum Mol Genet 25:1619-36
Brady, Lillian J; Bartley, Aundrea F; Li, Qin et al. (2016) Transcriptional dysregulation causes altered modulation of inhibition by haloperidol. Neuropharmacology 111:304-313
Patterson, Kelsey C; Hawkins, Virginia E; Arps, Kara M et al. (2016) MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Hum Mol Genet 25:3303-3320

Showing the most recent 10 out of 168 publications