CI. 1 Rationale. The Light Microscopy Core (LMC;see www.uchsc.edu/liqhtmicroscopv) has proven to be a highly useful, successful multi-user (42 total, see Appendix Item 4) facility offering five state-of-the-art instruments. New technologies continually emerge, and we have an exciting opportunity nearly to double the size of the LMC with new, advanced instrumentation and technical expertise. We propose to combine with a facility in the Renal Division of the Department of Medicine, which has been developed by Dr. Moshe Levi (Professor of Medicine, Physiology and Biophysics;Vice Chair of Medicine for Research). Until recently, the two facilities were entirely separate, in terms of instrumentation, space, users, administration, and funding. This situation arose because the Health Sciences Center built and moved to an entirely new $2.2B campus. The move occurred over about six years and was completed in January 2009. The LMC was one of the first to move, while the Department of Medicine Core was one of the last. Thus, for about five years the two cores operated entirely independently. Now that they are on the same campus (in adjacent buildings connected by a heated bridge), we have an opportunity to combine them, and make available to RMNDC users new instruments, at no additional chiarge to them. In addition, a campus-wide quinquennial Research Retreat is scheduled for November, 2009, and Light Microscopy has been selected by the central administration as one of three areas identified for special consideration. The likely upshot will be significant investment of intramural funds by the School of Medicine in the new, combined core. Dr. Betz is co-chair with Dr. Levi of the committee charged with presenting a long range plan at the Retreat. While still in the planning stages, a major goal is the purchase of new advanced instruments. Already his committee has identified several instruments of interest to multiple users (e.g., advanced spinning disk microscope with microlens illumination, STimulated Emission Depletion (STED) microscope).

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS048154-09
Application #
8585908
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
9
Fiscal Year
2014
Total Cost
$191,942
Indirect Cost
$66,490
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Lupo, J Eric; Koka, Kanthaiah; Jenkins, Herman A et al. (2014) Vibromechanical assessment of active middle ear implant stimulation in simulated middle ear effusion: a temporal bone study. Otol Neurotol 35:470-5
Kulbe, Jacqueline R; Mulcahy Levy, Jean M; Coultrap, Steven J et al. (2014) Excitotoxic glutamate insults block autophagic flux in hippocampal neurons. Brain Res 1542:12-9
Barcomb, Kelsey; Buard, Isabelle; Coultrap, Steven J et al. (2014) Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength. FASEB J 28:3810-9
Chen, Jian-Fu; Zhang, Ying; Wilde, Jonathan et al. (2014) Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nat Commun 5:3885
Nguyen, Linda M; Pozzoli, Marina; Hraha, Thomas H et al. (2014) Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes. Diabetes 63:1685-97
Hoffman, P L; Saba, L M; Flink, S et al. (2014) Genetics of gene expression characterizes response to selective breeding for alcohol preference. Genes Brain Behav 13:743-57
Moreno, Rosa L; Ribera, Angeles B (2014) Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability. Neural Dev 9:19
Carlisle, Tara C; Ribera, Angeles B (2014) Connexin 35b expression in the spinal cord of Danio rerio embryos and larvae. J Comp Neurol 522:861-75
Wang, Yuying; Pan, Luyuan; Moens, Cecilia B et al. (2014) Notch3 establishes brain vascular integrity by regulating pericyte number. Development 141:307-17
Pearson, Jennifer N; Schulz, Kalynn M; Patel, Manisha (2014) Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus. Epilepsy Res 108:1032-40

Showing the most recent 10 out of 49 publications