CI. 1 Rationale. The Light Microscopy Core (LMC;see has proven to be a highly useful, successful multi-user (42 total, see Appendix Item 4) facility offering five state-of-the-art instruments. New technologies continually emerge, and we have an exciting opportunity nearly to double the size of the LMC with new, advanced instrumentation and technical expertise. We propose to combine with a facility in the Renal Division of the Department of Medicine, which has been developed by Dr. Moshe Levi (Professor of Medicine, Physiology and Biophysics;Vice Chair of Medicine for Research). Until recently, the two facilities were entirely separate, in terms of instrumentation, space, users, administration, and funding. This situation arose because the Health Sciences Center built and moved to an entirely new $2.2B campus. The move occurred over about six years and was completed in January 2009. The LMC was one of the first to move, while the Department of Medicine Core was one of the last. Thus, for about five years the two cores operated entirely independently. Now that they are on the same campus (in adjacent buildings connected by a heated bridge), we have an opportunity to combine them, and make available to RMNDC users new instruments, at no additional chiarge to them. In addition, a campus-wide quinquennial Research Retreat is scheduled for November, 2009, and Light Microscopy has been selected by the central administration as one of three areas identified for special consideration. The likely upshot will be significant investment of intramural funds by the School of Medicine in the new, combined core. Dr. Betz is co-chair with Dr. Levi of the committee charged with presenting a long range plan at the Retreat. While still in the planning stages, a major goal is the purchase of new advanced instruments. Already his committee has identified several instruments of interest to multiple users (e.g., advanced spinning disk microscope with microlens illumination, STimulated Emission Depletion (STED) microscope).

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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University of Colorado Denver
United States
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Sinnen, Brooke L; Bowen, Aaron B; Forte, Jeffrey S et al. (2017) Optogenetic Control of Synaptic Composition and Function. Neuron 93:646-660.e5
Soltys, John N; Meyer, Stephanie A; Schumann, Hannah et al. (2017) Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy. Biophys J 112:1692-1702
Goodell, Dayton J; Zaegel, Vincent; Coultrap, Steven J et al. (2017) DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep 19:2231-2243
Moreno, Rosa L; Josey, Megan; Ribera, Angeles B (2017) Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons. J Vis Exp :
Dittmer, Philip J; Wild, Angela R; Dell'Acqua, Mark L et al. (2017) STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep 19:321-334
Gilmer, Jesse I; Person, Abigail L (2017) Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity. J Neurosci 37:12153-12166
Westacott, Matthew J; Ludin, Nurin W F; Benninger, Richard K P (2017) Spatially Organized ?-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans. Biophys J 113:1093-1108
Lam, Philip M; Carlsen, Jessica; González, Marco I (2017) A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. Neurobiol Dis 102:1-10
McElroy, Pallavi B; Liang, Li-Ping; Day, Brian J et al. (2017) Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation. Exp Neurol 298:13-22
Westacott, Matthew J; Farnsworth, Nikki L; St Clair, Joshua R et al. (2017) Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes 66:2436-2445

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