04 Core D: Machine Shop. C4.1 Rationale. Core D provides machine shop support services to enable (1) specialized imaging, (2) electrical recording and behavioral methods - major features of UCD neuroscience research. As evidenced in section 04.4, the shop provides the ability go beyond the out-of-the-box instrumentation and accessories that are available commercially. We have the ability to alter commercial instruments and equipment to our own specifications, and more importantly to build customized versions from scratch. As such, the shop core allows infrastructure to evolve and change over time ahead of commercially available instruments thereby allowing users to use instruments that lead the application of advanced/novel technologies to neuroscience research. While the main goal is to provide products that aren't commercially available, the shop provides rapid access to products on an as-needed basis, particularly when commercial availability is slow (e.g. electrode holders and amplifier headstage mounts for electrophysiological recording and microscope mounts and stage adaptors for confocal microscopy). In addition, the shop routinely modifies products to meet specific needs.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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University of Colorado Denver
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Lupo, J Eric; Koka, Kanthaiah; Jenkins, Herman A et al. (2014) Vibromechanical assessment of active middle ear implant stimulation in simulated middle ear effusion: a temporal bone study. Otol Neurotol 35:470-5
Kulbe, Jacqueline R; Mulcahy Levy, Jean M; Coultrap, Steven J et al. (2014) Excitotoxic glutamate insults block autophagic flux in hippocampal neurons. Brain Res 1542:12-9
Barcomb, Kelsey; Buard, Isabelle; Coultrap, Steven J et al. (2014) Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength. FASEB J 28:3810-9
Chen, Jian-Fu; Zhang, Ying; Wilde, Jonathan et al. (2014) Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nat Commun 5:3885
Nguyen, Linda M; Pozzoli, Marina; Hraha, Thomas H et al. (2014) Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes. Diabetes 63:1685-97
Hoffman, P L; Saba, L M; Flink, S et al. (2014) Genetics of gene expression characterizes response to selective breeding for alcohol preference. Genes Brain Behav 13:743-57
Moreno, Rosa L; Ribera, Angeles B (2014) Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability. Neural Dev 9:19
Carlisle, Tara C; Ribera, Angeles B (2014) Connexin 35b expression in the spinal cord of Danio rerio embryos and larvae. J Comp Neurol 522:861-75
Wang, Yuying; Pan, Luyuan; Moens, Cecilia B et al. (2014) Notch3 establishes brain vascular integrity by regulating pericyte number. Development 141:307-17
Pearson, Jennifer N; Schulz, Kalynn M; Patel, Manisha (2014) Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus. Epilepsy Res 108:1032-40

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