Core A ? Optogenetics and Neural Engineering: Project Summary (Abstract) The overall goal of the Optogenetics and Neural Engineering (ONE) Core is to enhance existing neuroscience research programs on the University of Colorado Anschutz Medical Campus (UC-AMC) by providing support for experiments and quantitative analysis. Specifically, the ONE Core will facilitate the adoption and optimization of optogenetic techniques in users' research by providing optical equipment and technical expertise (Aim 1), reducing the significant upfront costs required to leverage the advantages of optogenetics. Proof-of-principle for executing this Aim of the ONE Core is provided by the UC School of Medicine-supported Optogenetics Pilot Program, which has confirmed both the need for, and impact of, supporting optogenetic approaches at UC-AMC. In addition, the ONE Core will provide support for quantitative analysis and the development of experimental equipment (Aim 2). By achieving these Aims, the ONE Core will enhance a broad range of strong neuroscience research at UC-AMC consistent with the mission of the NINDS to obtain basic information about nervous system function and ultimately decrease the burden of neurological disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS048154-13
Application #
9402664
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
13
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Sinnen, Brooke L; Bowen, Aaron B; Forte, Jeffrey S et al. (2017) Optogenetic Control of Synaptic Composition and Function. Neuron 93:646-660.e5
Soltys, John N; Meyer, Stephanie A; Schumann, Hannah et al. (2017) Determining the Spatial Relationship of Membrane-Bound Aquaporin-4 Autoantibodies by STED Nanoscopy. Biophys J 112:1692-1702
Goodell, Dayton J; Zaegel, Vincent; Coultrap, Steven J et al. (2017) DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep 19:2231-2243
Moreno, Rosa L; Josey, Megan; Ribera, Angeles B (2017) Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons. J Vis Exp :
Dittmer, Philip J; Wild, Angela R; Dell'Acqua, Mark L et al. (2017) STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep 19:321-334
Gilmer, Jesse I; Person, Abigail L (2017) Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity. J Neurosci 37:12153-12166
Westacott, Matthew J; Ludin, Nurin W F; Benninger, Richard K P (2017) Spatially Organized ?-Cell Subpopulations Control Electrical Dynamics across Islets of Langerhans. Biophys J 113:1093-1108
Lam, Philip M; Carlsen, Jessica; González, Marco I (2017) A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. Neurobiol Dis 102:1-10
McElroy, Pallavi B; Liang, Li-Ping; Day, Brian J et al. (2017) Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation. Exp Neurol 298:13-22
Westacott, Matthew J; Farnsworth, Nikki L; St Clair, Joshua R et al. (2017) Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets. Diabetes 66:2436-2445

Showing the most recent 10 out of 118 publications