The Behavioral Testing Core is housed within two rooms in the basement of BBSRB. B028 is a dedicated room for behavioral assessment of rats, in which the Core has the capability of performing a) cognitive testing of learning and memory using a Morris water maze system, b) sensory testing using a whisker nuisance task, c) nociceptive testing using a Hargreaves plantar device, and d) locomotor function testing using the Basso, Beattie, Bresnahan (BBB) scale and the foot misplacement apparatus (horizontal ladder). B030 is a dedicated room for behavioral assessment of mice, in which the Core has the capability of performing cognitive testing of learning and memory using a white Morris water maze (for black mice) or a black maze (for white mice) in conjunction with an updated digital tracking system. Mice can also be evaluated for sensorimotor function using a corner turn test, vestibulomotor ability using the rotarod apparatus, and simple and complex motor function using the composite neuroscore, neurological severity score. Basso mouse scale (BMS), grip strength meter, and string test. Specific instruments purchased with P30 funds include 2 AccuScan Instruments EzVideoDV Automated Tracking System Digital Systems, a Columbus Instruments Rotamex-5 and Foot Misplacement Apparatus, 2 analgesia meters and a wading pool for open field locomotor assessment. Kathryn Saatman, Ph.D. directs the Behavioral Testing Core along with Assistant Core Director, Alexander Rabchevsky. Stephen Onifer, Ph.D provide day-to-day management of core operations and overseeing training, data storage and dissemination, and core usage. Two senior technicians who are trained in behavioral testing in rodent TBI models (Ms. Jennifer Pleasant, 25% effort) and SCI models (Mr. Travis Lyttle, 25% effort) assist and instruct new core users with the behavioral assessments.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
United States
Zip Code
Yonutas, Heather M; Pandya, Jignesh D; Sullivan, Patrick G (2015) Changes in mitochondrial bioenergetics in the brain versus spinal cord become more apparent with age. J Bioenerg Biomembr 47:149-54
Carlson, Shaun W; Madathil, Sindhu K; Sama, Diana M et al. (2014) Conditional overexpression of insulin-like growth factor-1 enhances hippocampal neurogenesis and restores immature neuron dendritic processes after traumatic brain injury. J Neuropathol Exp Neurol 73:734-46
Bolton, Amanda N; Saatman, Kathryn E (2014) Regional neurodegeneration and gliosis are amplified by mild traumatic brain injury repeated at 24-hour intervals. J Neuropathol Exp Neurol 73:933-47
Pandya, Jignesh D; Readnower, Ryan D; Patel, Samir P et al. (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp Neurol 257:106-13
Miller, Darren M; Wang, Juan A; Buchanan, Ashley K et al. (2014) Temporal and spatial dynamics of nrf2-antioxidant response elements mediated gene targets in cortex and hippocampus after controlled cortical impact traumatic brain injury in mice. J Neurotrauma 31:1194-201
Srodulski, Sarah; Sharma, Savita; Bachstetter, Adam B et al. (2014) Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin. Mol Neurodegener 9:30
Singh, Ranjana; Brewer, M Kathryn; Mashburn, Charles B et al. (2014) Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies. J Biol Chem 289:19383-94
Yu, C G; Singh, R; Crowdus, C et al. (2014) Fenbendazole improves pathological and functional recovery following traumatic spinal cord injury. Neuroscience 256:163-9
Patel, Samir P; Sullivan, Patrick G; Pandya, Jignesh D et al. (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp Neurol 257:95-105
Miller, Darren M; Singh, Indrapal N; Wang, Juan A et al. (2013) Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo. Free Radic Biol Med 57:1-9

Showing the most recent 10 out of 51 publications