The Behavioral Testing Core is housed within two rooms in the basement of BBSRB. B028 is a dedicated room for behavioral assessment of rats, in which the Core has the capability of performing a) cognitive testing of learning and memory using a Morris water maze system, b) sensory testing using a whisker nuisance task, c) nociceptive testing using a Hargreaves plantar device, and d) locomotor function testing using the Basso, Beattie, Bresnahan (BBB) scale and the foot misplacement apparatus (horizontal ladder). B030 is a dedicated room for behavioral assessment of mice, in which the Core has the capability of performing cognitive testing of learning and memory using a white Morris water maze (for black mice) or a black maze (for white mice) in conjunction with an updated digital tracking system. Mice can also be evaluated for sensorimotor function using a corner turn test, vestibulomotor ability using the rotarod apparatus, and simple and complex motor function using the composite neuroscore, neurological severity score. Basso mouse scale (BMS), grip strength meter, and string test. Specific instruments purchased with P30 funds include 2 AccuScan Instruments EzVideoDV Automated Tracking System Digital Systems, a Columbus Instruments Rotamex-5 and Foot Misplacement Apparatus, 2 analgesia meters and a wading pool for open field locomotor assessment. Kathryn Saatman, Ph.D. directs the Behavioral Testing Core along with Assistant Core Director, Alexander Rabchevsky. Stephen Onifer, Ph.D provide day-to-day management of core operations and overseeing training, data storage and dissemination, and core usage. Two senior technicians who are trained in behavioral testing in rodent TBI models (Ms. Jennifer Pleasant, 25% effort) and SCI models (Mr. Travis Lyttle, 25% effort) assist and instruct new core users with the behavioral assessments.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
United States
Zip Code
Zhang, Bei; Bailey, William M; McVicar, Anna Leigh et al. (2016) Age increases reactive oxygen species production in macrophages and potentiates oxidative damage after spinal cord injury. Neurobiol Aging 47:157-167
Hall, Edward D; Wang, Juan A; Bosken, Jeffrey M et al. (2016) Lipid peroxidation in brain or spinal cord mitochondria after injury. J Bioenerg Biomembr 48:169-74
Meier, Shelby; Bell, Michelle; Lyons, Danielle N et al. (2016) Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis. J Neurosci 36:1001-7
Kulbe, Jacqueline R; Geddes, James W (2016) Current status of fluid biomarkers in mild traumatic brain injury. Exp Neurol 275 Pt 3:334-52
Ghoshal, Sarbani; Bondada, Vimala; Saatman, Kathryn E et al. (2016) Phage display for identification of serum biomarkers of traumatic brain injury. J Neurosci Methods 272:33-37
Meyer, Carolyn A; Singh, Ranjana; Jones, Mackenzie T et al. (2016) Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression, but Does Not Improve Locomotor Function, following Spinal Cord Injury. PLoS One 11:e0147716
Miller, Darren M; Singh, Indrapal N; Wang, Juan A et al. (2015) Nrf2-ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in mice. Exp Neurol 264:103-10
Yonutas, Heather M; Pandya, Jignesh D; Sullivan, Patrick G (2015) Changes in mitochondrial bioenergetics in the brain versus spinal cord become more apparent with age. J Bioenerg Biomembr 47:149-54
Zhang, Bei; Bailey, William M; Braun, Kaitlyn J et al. (2015) Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury. Exp Neurol 273:83-91
Meier, Shelby; Bell, Michelle; Lyons, Danielle N et al. (2015) Identification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brain. J Alzheimers Dis 48:687-702

Showing the most recent 10 out of 73 publications